کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5532850 1402082 2017 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewThe Journey of the Autophagosome through Mammalian Cell Organelles and Membranes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
ReviewThe Journey of the Autophagosome through Mammalian Cell Organelles and Membranes
چکیده انگلیسی


- Autophagosome are formed from at ER membrane sites supplied with other endo-membranes.
- Autophagosome are tightly connected with trafficking machineries and pathways in the cell.
- Autophagy induction and regulation are often dependant on endo-membranes signaling machineries.

Autophagy is an intracellular degradation process carried out by a double-membrane organelle, termed the autophagosome, which sequesters cytoplasmic material destined for lysosomal degradation and recycling. Autophagy and autophagosome biogenesis are highly conserved processes in eukaryotes and are essential for cell survival, stress responses, and homeostasis. Autophagosomes are dynamic and complex organelles that can originate from several different membrane compartments. Autophagosomes traffic through the cell to fuse with lysosomes or other compartments. Despite identification of key proteins necessary for autophagosome assembly and transport, such as those encoded by the autophagy-related genes, the relationship and interdependence of the autophagosome with other intracellular endo-membranes, including those of organelles involved in exocytosis and endocytic trafficking pathways, are still poorly understood. Here we discuss formation of autophagosomes, the journey of these organelles through the cell, and their close interplay with other mammalian organelles from points of view of signalization platforms and membrane dynamics.

Graphical Abstract160

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 429, Issue 4, 17 February 2017, Pages 497-514
نویسندگان
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