کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5532936 | 1402089 | 2017 | 14 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Mechanism of Action of ABC Importers: Conservation, Divergence, and Physiological Adaptations Mechanism of Action of ABC Importers: Conservation, Divergence, and Physiological Adaptations](/preview/png/5532936.png)
- ABC transporters have diverse physiological roles.
- Different 3D folds of the transmembrane domain have been conserved.
- Each fold is associated with a different mechanism of action.
- The different mechanisms are tuned to the physiological role of the system.
The past decade has seen a remarkable surge in structural characterization of ATP binding cassette (ABC) transporters, which have spurred a more focused functional analysis of these elaborate molecular machines. As a result, it has become increasingly apparent that there is a substantial degree of mechanistic variation between ABC transporters that function as importers, which correlates with their physiological roles. Here, we summarize recent advances in ABC importers' structure-function studies and provide an explanation as to the origin of the different mechanisms of action.
Graphical Abstract286
Journal: Journal of Molecular Biology - Volume 429, Issue 5, 10 March 2017, Pages 606-619