کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5533621 1550395 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Review articleExosomes as agents of change in the cardiovascular system
ترجمه فارسی عنوان
بررسی اگزوزومها به عنوان عوامل تغییر در سیستم قلبی عروقی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


- Exosomes transfer active nucleic acids and proteins between cells and can alter cellular phenotypes.
- Therapeutic benefits of stem cells in cardiac treatment mediated by exosomes
- Exosomes are promising as prognostic markers in cardiovascular disease.
- Exosomes can be potentially manipulated to deliver targeted cargo to cells.

Exosomes have an evolving role in paracrine and autocrine signaling, which is enhanced because these lipid vesicles are quite stable and can deliver miRNA, DNA, protein and other molecules to cells throughout the body. Most cell types release exosomes, and exosomes are found in all biological fluids, making them accessible biomarkers. Significantly, exosomes can carry a biologically potent cargo, which can alter the phenotype of recipient cells. In the cardiovascular system exosomes have been primarily studied for their role in mediating the beneficial effects of mesenchymal stem cells after myocardial injury. Exosomes released by cardiac cells in disease states, such as myocardial ischemia, can potentially have important pathophysiologic effects on other cardiac cells as well as on distant organs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 111, October 2017, Pages 40-50
نویسندگان
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