کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534146 1550832 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ulipristal acetate administration at mid-cycle changes gene expression profiling of endometrial biopsies taken during the receptive period of the human menstrual cycle
ترجمه فارسی عنوان
تجویز استات بالائپریستال در اواسط چرخه تغییر مشخصات ژن از بیوپسی اندومتری که در طول دوره پذیرش چرخه قاعدگی انسان گرفته شده است
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


- Ulipristal acetate administration at mid-cycle has anti PR effects on endometrium.
- Genomic data in Ulipristal-treated subjects are compatible with a non-receptive endometrium.
- Ulipristal is a potent emergency contraceptive due to its effects on endometrium.

The aim of this study was to analyze the effects of mid-cycle administration of Ulipristal acetate (UPA) on gene expression in endometrial biopsies taken during the receptive phase of the cycle. Fourteen healthy menstruating women were studied during 14 control non-treated and 12 treated cycles with a single dose of 30 mg UPA when follicle diameter reached 20 mm. Ovulation in both treated and control cycles was confirmed by serial determinations of serum LH, progesterone and vaginal ultrasound. An endometrial biopsy at day LH+7, in each cycle, was taken for RNA microarray and qPCR analysis or prepared for histological and immunohistochemistry studies. Functional analysis of differentially expressed genes showed the presence of changes compatible with a non-receptive endometrial phenotype, further confirmed by qPCR and immunohistochemistry. This study suggests the effects of UPA on endometrial receptivity, offering a plausible explanation for the higher contraceptive efficacy of this method compared to that of levonorgestrel.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Endocrinology - Volume 447, 15 May 2017, Pages 1-11
نویسندگان
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