کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5534455 | 1551129 | 2016 | 6 صفحه PDF | دانلود رایگان |
- Aquaporin-4 (AQP4) water channels in astrocytes regulate basal brain water content.
- AQP4 is not involved in draining CSF through arachnoid villi or lymphatic vessels.
- Ependymal AQP4 does not have any major effect on basal brain water content.
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content was increased in mice with a complete loss of aquaporin-4 (AQP4) water channels (global Aqp4â/â mice), but not in mice with a selective removal of perivascular AQP4 or in a novel mouse line with a selective deletion of ependymal AQP4 (Foxj1-Cre:Aqp4flox/flox mice). Unique for the global Aqp4â/â mice is the loss of the AQP4 pool subjacent to the pial membrane. Our data suggest that water accumulates in brain when subpial AQP4 is missing, pointing to a critical role of this pool of water channels in brain water exit.
Journal: Molecular and Cellular Neuroscience - Volume 77, December 2016, Pages 47-52