کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5534459 1551129 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4
چکیده انگلیسی


- Migrating neuronal progenitors express the four ErbB4 isoforms.
- Neuregulin1α and β are expressed in medial ganglionic eminence and in the cortex.
- Both neuregulin1α and β can activate neuronal progenitor migration.
- Migratory activity correlates with AKT phosphorylation level.
- The ErbB4 isoforms display different responses to neuregulin1α and β.

Deficits in neuronal migration during development in the central nervous system may contribute to psychiatric diseases. The ligand neuregulin1 (NRG1) and its receptor ErbB4 are genes conferring susceptibility to schizophrenia, playing a key role in the control of neuronal migration both during development and adulthood.Several NRG1 and ErbB4 isoforms were identified, which deeply differ in their characteristics. Here we focused on the four ErbB4 isoforms and the two NRG1 isoforms differing in their EGF-like domain, namely α and β. We hypothesized that these isoforms, which are differently regulated in schizophrenic patients, could play different roles in neuronal migration. Our hypothesis was strengthened by the observation that both NRG1α and NRG1β and the four ErbB4 isoforms are expressed in the medial and lateral ganglionic eminences and in the cortex during development in rat. We analysed in vitro the signal transduction pathways activated by the different ErbB4 isoforms following the treatment with soluble recombinant NRG1α or NRG1β and the ability to stimulate migration.Our data show that two ErbB4 isoforms, namely JMa-cyt2 and JMb-cyt1, following NRG1α and NRG1β treatment, strongly activate AKT phosphorylation, conferring high migratory activity to neuronal progenitors, thus demonstrating that both NRG1α and NRG1β can play a role in neuronal migration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular and Cellular Neuroscience - Volume 77, December 2016, Pages 87-94
نویسندگان
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