Keywords: ADAM; a disintegrin and metalloprotease; EGFR; epidermal growth factor receptor; ELANE; elastase, neutrophil expressed; ERK; extracellular signal-regulated kinase; GC; gastric cancer; gp130; glycoprotein 130; IL-11; interleukin-11; JAK; janus kinase; MAPK
مقالات ISI (ترجمه نشده)
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Keywords: Proteolysis; ADAM17; Interleukins; Trans-signaling; Cleavage site;
Keywords: Interleukin-11; Interleukin-6; Interleukin-11 receptor; Interleukin-6 receptor; gp130; Signal transduction; Trans-signaling; Protease; ADAM17; ADAM10;
Keywords: Insulin resistance; Inflammatory markers; Bile acids; ADAM17; Adipokines; CytokinesADAM17, A disintegrin and metalloproteinase; CIDE, Cell death inducing DNA fragmentation factor; HOMA, Homeostasis model assessment; TIMP, Tissue inhibitor of metalloprotei
Keywords: ADAM17; Metalloprotease; Exosites; Glycosylation
Keywords: ADAM17; Inflammation; Interleukin-6; Soluble receptor; Trans-signaling; sgp130Fc
Keywords: Fluorescent substrate; ADAM17; ADAM9; Assay; Extracellular vesicles; ADAM10ADAM, a disintegrin and metalloproteinase; TNF-alpha, tumor necrosis factor-alpha; TACE, TNF-alpha-converting enzyme; ELISA, enzyme-linked immunosorbent assay; FRET, fluorescence r
Metalloprotease ADAM17 regulates porcine epidemic diarrhea virus infection by modifying aminopeptidase N
Keywords: PEDV; ADAM17; Aminopeptidase N;
Knockdown of ADAM17 inhibits cell proliferation and increases oxaliplatin sensitivity in HCT-8 colorectal cancer through EGFR-PI3K-AKT activation
Keywords: ADAM17; EGFR/PI3K/AKT signaling pathway; Colorectal cancer; Chemoresistance;
HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles
Keywords: Hck; Chronic HIV infection; Nef; ADAM17; Plasma extracellular vesicles; Liver; Hepatocytes; Myeloid cells;
Anoctamin-6 regulates ADAM sheddase function
Keywords: Scramblase; Anoctamin-6; Phosphatidylserine; ADAM17; Shedding;
Ursolic acid prevents angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice
Keywords: Abdominal aortic aneurysm; Inï¬ammation; Ursolic acid; ADAM17; STAT3; MMPs;
ADAM17 promotes cell migration and invasion through the integrin β1 pathway in hepatocellular carcinoma
Keywords: ADAM17; A disintegrin and metalloproteinase-17; ADAMTS; ADAMs with thrombospondin motifs; bFGF; Basic fibroblast growth factor; EGF; epidermal growth factor; ECM; extracellular matrix; GDAC; Genome Data Analysis Center; HCC; hepatocellular carcinoma; MMP;
The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis
Keywords: ACAT; Acyl-CoA:cholesterol acyltransferase; ADAM17; a disintegrin and metalloproteinase 17; APO; apolipoprotein; COL18; collagen XVIII; CS/DS; chondroitin sulfate/dermatan sulfate; FLOT1; flotilin-1; GLCE; C5 epimerase; GPIHBP1; glycosylphosphatidylinosit
Early diagnostic evaluation of miR-122 and miR-224 as biomarkers for hepatocellular carcinoma
Keywords: Diagnosis; Hepatocellular carcinoma; miR-122; miR-224; Sensitivity; ADAM17; A disintegrin and metalloprotease domain-containing protein 17; AFP; Alpha-fetoprotein; AKT; AKT/Protein kinase B; ALP; Alkaline phosphatase; ALT; Alanine aminotransferase; ANOVA;
Regulation of brown and beige fat by microRNAs
Keywords: ADAM17; ADAM metallopeptidase domain 17; ADINR; adipogenic differentiation induced noncoding RNA; ADNCR; adipocyte differentiation-associated long noncoding RNA; AMPK; AMP-activated protein kinase; aP2; fatty-acid binding protein 4; BAT; brown adipose tis
Changes in expressions of ADAM9, 10, and 17 as well as α-secretase activity in renal cell carcinoma
Keywords: α-Secretase; ADAM10; ADAM9; ADAM17; Renal cell carcinoma; Human;
Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo
Keywords: Pancreatic ductal adenocarcinoma (PDAC); ADAM17; Inhibitory antibody; Tumorigenesis; Targeted therapy;
Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region
Keywords: ADAM17; Activation; Regulation; Shedding; Catalytic activity; Structure; Metalloproteases;
ReviewMerlin, the product of NF2 gene, is associated with aromatase expression and estrogen formation in human liver tissues and liver cancer cells
Keywords: NF2; neurofibromatosis type 2; HCC; hepatocellular carcinoma; ARO; aromatase; AREG; amphiregulin; ER; estrogen receptors; ADAM17; a disintegrin and metalloprotease 17; TACE; tumor necrosis α converting enzyme; Merlin; moesin-ezrin-radixin-like protein; H
AT1 receptor signaling pathways in the cardiovascular system
Keywords: AAA; abdominal aortic aneurysm; ADAM17; a disintegrin and metalloproteinase 17; ANO1; anoctamin-1; ARAP1; type 1 angiotensin II receptor-associated protein; ATRAP; AT1 receptor associated protein; AngII; angiotensin II; AT1 receptor; angiotensin II type 1
Research paperInfluence of haplotypes, gene expression and soluble levels of L-selectin on the risk of acute coronary syndrome
Keywords: ACS; acute coronary syndrome; ACC; American College of Cardiology; ADAM17; a disintegrin and metalloproteinase 17; BMI; body mass index; bp; base pairs; cDNA; complementary deoxyribonucleic acid; CG; control group; CPK; creatine phosphokinase; Cq; quantif
The plasma membrane: Penultimate regulator of ADAM sheddase function
Keywords: ADAM17; ADAM10; Activation; Cell membrane asymmetry; Scramblases;
Tumor necrosis factor-alpha and soluble TNF-alpha receptor responses in young vs. middle-aged males following eccentric exercise
Keywords: Inflammation; Aging; Resistance exercise; Muscle damage; Recovery; 120P; 120-minute post-muscle damaging protocol; 1-RM; 1-repetition maximum; 24H; 24-hour post-muscle damaging protocol; 30P; 30-minute post-muscle damaging protocol; 48H; 48-hour post-musc
The shedding protease ADAM17: Physiology and pathophysiology
Keywords: ADAM proteases; ADAM17; IL-6R; IL-6 trans-signaling; Shedding; EGF receptor; iPS cell system;
Molecular design and structural optimization of potent peptide hydroxamate inhibitors to selectively target human ADAM metallopeptidase domain 17
Keywords: ADAM17; ADAM10; Peptide hydroxamate; Selective inhibitor; Inflammatory bowel disease
Neuregulin1 alpha activates migration of neuronal progenitors expressing ErbB4
Keywords: ADAM17; A disintegrin and metalloprotease 17; AKT; cellular homolog of murine thymoma virus akt8 oncogene; ErbB; v-erb-a erythroblastic leukemia viral oncogene homolog; df; degree of freedom; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehy
Soluble SEMA4D/CD100: A novel immunoregulator in infectious and inflammatory diseases
Keywords: ADAM17; a disintegrin and metalloproteinase domain 17; ADAMTS4; a disintegrin and metalloproteinase with thrombospondin motif 4; CRP; C-reactive protein; EAE; experimental autoimmune encephalomyelitis; HFRS; hemorrhagic fever with renal syndrome; HTLV-1;
Inactive rhomboid proteins: New mechanisms with implications in health and disease
Keywords: ADAM17; a disintegrin and metalloproteinase 17; COG; conserved oligomeric Golgi; Der1; degradation in the ER 1; Dfm1; Der1-like family member 1; DKO; double knockout; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; ERAD; ER-associated d
Mini reviewA gradient of glucocorticoid sensitivity among helper T cell cytokines
Keywords: ADAM17; ADAM Metallopeptidase Domain 17; ADH; alcohol dehydrogenase; AHR; aryl hydrocarbon receptor; AP-1; activator protein 1; BCL; B-cell lymphoma; BIM; Bcl-2 interacting mediator of cell death; CBP; CREB-binding protein; CCL; CC chemokine ligands; CXCL
HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection
Keywords: Extracellular vesicles; HIV; Nef; ADAM17; Vpu; HIV reservoir; Chronic HIV infection
In silico approaches and proportional odds model towards identifying selective ADAM17 inhibitors from anti-inflammatory natural molecules
Keywords: ADAM17; MMP; Natural molecules; Molecular dynamic simulation; Proportional odds model;
Rhomboid protease inhibitors: Emerging tools and future therapeutics
Keywords: ABP; activity based probe; ADAM17; a disintegrin and metalloproteinase 17; cmk; chloromethylketone; cho; aldehyde; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; FRET; Foerster resonance energy transfer; iRhom; inactive rhomboid hom
HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection
Keywords: HIV Nef; ADAM17; Plasma extracellular vesicles; Endosomal secretion; Notch1;
Recruitment of CD16+ monocytes to endothelial cells in response to LPS-treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine
Keywords: 7AAD; 7-aminoactinomycin; ADAM17; a disintegrin and metallopeptidase domain 17; BB94; batimastat; CBA; cytometric bead array; CCR2; chemokine (C-C motif) receptor 2; CD14; monocyte differentiation antigen CD14; CD16; Fcγ receptor III (FcγRIII); CX3CR1;
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling
Keywords: interleukin-11; ADAM10; ADAM17; proteolysis; signal transduction
Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes
Keywords: Metalloproteinase; ADAM17; ADAM10; exosomes; shedding; inflammation;
Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells
Keywords: 2AB; 2-aminobenzamide; ALCAM; Activated leukocyte cell adhesion molecule; ALCAMe; Endogenous ALCAM from MDA-MB-231 cells; ALCAMgly; Recombinant glycosylated ALCAM expressed in HEK-293 cells; ALCAMnongly; Non-glycosylated ALCAM; ADAM17; A disintegrin and m
Asthma and lower airway diseaseCounterregulation between thymic stromal lymphopoietin- and IL-23-driven immune axes shapes skin inflammation in mice with epidermal barrier defects
Keywords: Epidermal barrier; corneodesmosin; atopic dermatitis; peeling skin syndrome type B; thymic stromal lymphopoietin; IL-23; TH2; TH17; IL-1β; skin inflammation; mouse model; AD; Atopic dermatitis; ADAM17; A disintegrin and metalloproteinase 17; CDSN; Corneo
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
Loss of ADAM17 is associated with severe multiorgan dysfunction
Keywords: ADAM17; Exome sequencing; Congenital enteropathy; Immunodeficiency; Inflammation
A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis
Keywords: Atherosclerosis; Cardiovascular disease outcomes; Endothelium-derived factors; Follow up study; Inflammation; ADAM17; A Disintegrin and Metallo Protease Domain 17; MACEs; Major cardiovascular events; CV; Cardiovascular; TIMP3; Tissue inhibitor of metallop
MiR-145, a microRNA targeting ADAM17, inhibits the invasion and migration of nasopharyngeal carcinoma cells
Keywords: MiR-145; Nasopharyngeal carcinoma; ADAM17; Invasion; Migration
Molecular characterization of a disintegrin and metalloprotease-17 (ADAM17) in granulosa cells of bovine preovulatory follicles
Keywords: LH; luteinizing hormone; hCG; human chorionic gonadotropin; COC; cumulus-oocyte complex; PTGS2; prostaglandin synthase 2; TNFAIP6; tumor necrosis factor-alpha-induced protein 6; EGFR; epidermal growth factor receptor; EREG; epiregulin; AREG; amphiregulin;
Differential regulation of TROP2 release by PKC isoforms through vesicles and ADAM17
Keywords: TROP2; PKC; Ectodomain shedding; Microvesicles; ADAM17;
Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling
Keywords: ADAM17; A disintegrin and metalloproteinase 17; Ang II; angiotensin II; CGT; cilengitide; CsA; cyclosporine A; DAG; diacylglycerol; FSGS; focal and segmental glomerulosclerosis; GBM; glomerular basement membrane; NFATc1; nuclear factor of activated T-cell
MPTP activates ASK1-p38 MAPK signaling pathway through TNF-dependent Trx1 oxidation in parkinsonism mouse model
Keywords: 6-OHDA; 6-hydroxydopamine; ADAM17; ADAM metallopeptidase domain 17; AMS; 4-acetamido-4â²-maleimidylstilbene-2, 2â²-disulfonic acid, disodium salt; ASK1; Apoptosis signal-regulating kinase 1; CIB1; Calcium and integrin-binding protein 1; C (in figure); V
A novel marker ADAM17 for clear cell renal cell carcinomas: Implication for patients' prognosis
Keywords: ADAM17; Prognosis; Renal cell carcinoma; Immunohistochemistry;
MicroRNAs are key regulators of brown adipogenesis
Keywords: BAT; brown adipose tissue; WAT; white adipose tissue; iBAT; intrascapular brown adipose tissue; SAT; subcutaneous fat; Mef-2; myocyte enhancer factor-2; PGC-1α; Ppar-Ï co-activator; Prdm16; PR domain containing 16; C/ebpβ; CCAAT/enhancer-binding protei
MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17
Keywords: MiR-152; ADAM17; HUVEC; Atherosclerosis;