کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8302176 | 1537724 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
MicroRNAs are key regulators of brown adipogenesis
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کلمات کلیدی
MEF-2SATBATPRDM16PGC-1αIBATADAM17ADAM metallopeptidase domain 17UCP-1c/ebpβ - c / ebpβCCAAT/enhancer-binding protein β - CCAAT / پروتئین اتصال دهنده تقویت کننده βPPARs - PPAR هاBrown adipocytes - آدفوسیت های قهوه ایWhite adipose tissue - بافت چربی سفیدbrown adipose tissue - بافت چربی قهوه ایUncoupling protein-1 - جدا کردن پروتئین-1PR domain containing 16 - دامنه PR حاوی 16myocyte enhancer factor-2 - عامل افزایش دهنده myocyte-2Obesity - مرض چاقیMicroRNA - میکرو RNA Beige fat - چربی بژSubcutaneous fat - چربی زیر جلدیWAT - چیPeroxisome proliferator-activated receptors - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The recent discovery of microRNA, thousands of short, non-coding strands of RNA that regulate gene expressions on the transcriptional level throughout the body, raises the possibility of their roles as therapeutic targets in the treatment of a diverse range of diseases including diabetes, cancer, cardiovascular disease, and obesity. Specifically, their potential as therapeutic targets in the treatment of obesity has been highlighted. Brown adipose tissue containing a large number of mitochondria and expressing Ucp-1 is metabolically active through dissipating energy as heat in cold temperatures. Brown adipose, which was previously thought to be present only in neonatal and infants, has been recently unexpectedly identified in various anatomical regions of the adult human body. Furthermore, brown adipocytes have been shown to originate from skeletal and cardiovascular myoblast progenitor cells. Several identified microRNAs participate in the regulation of brown adipocyte differentiation through pathways involving the Prdm16 and C/ebp-β program. These miRNAs are potential therapeutic targets in the induction of brown adipocyte lineage differentiation from myoblast and white adipose, through which the Ucp-1 expression is regulated to increase calorie expenditure and reduce body weight in obese individuals. This review focuses on the current understanding of miRNAs on the regulation of brown adipogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 11, November 2014, Pages 1590-1595
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1841, Issue 11, November 2014, Pages 1590-1595
نویسندگان
Joseph Yi Zhou, Lixin Li,