کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5534989 | 1551363 | 2016 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inactive rhomboid proteins: New mechanisms with implications in health and disease
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کلمات کلیدی
TACETNFα-converting enzymeloop 1TNFendoplasmic reticulum-associated protein degradationTMEMconserved oligomeric golgiSREBPADAM17DKOEGFRERADSPPCoGInnate immunity - ایمنی ذاتیER-Associated Degradation - تخریب ER-AssociatedA disintegrin and metalloproteinase 17 - تخریب و متالوپروتئیناز 17Cancer - سرطانendoplasmic reticulum - شبکه آندوپلاسمی tumor necrosis factor - فاکتور نکروز تومورtransmembrane - فرابنفشdouble knockout - نابودی دوگانهknockout - ناکاوتSterol regulatory element-binding protein - پروتئین اتصال دهنده پروتئین Sterol RegulatoryTransmembrane protein - پروتئین ترانزیتیSignal peptide peptidase - پپتیداز پپتیدی سیگنالEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Rhomboids, proteases containing an unusual membrane-integral serine protease active site, were first identified in Drosophila, where they fulfill an essential role in epidermal growth factor receptor signaling, by cleaving membrane-tethered growth factor precursors. It has recently become apparent that eukaryotic genomes harbor conserved catalytically inactive rhomboid protease homologs, including derlins and iRhoms. Here we highlight how loss of proteolytic activity was followed in evolution by impressive functional diversification, enabling these pseudoproteases to fulfill crucial roles within the secretory pathway, including protein degradation, trafficking regulation, and inflammatory signaling. We distil the current understanding of the roles of rhomboid pseudoproteases in development and disease. Finally, we address mechanistically how versatile features of proteolytically active rhomboids have been elaborated to serve the sophisticated functions of their pseudoprotease cousins. By comparing functional and structural clues, we highlight common principles shared by the rhomboid superfamily, and make mechanistic predictions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 60, December 2016, Pages 29-37
Journal: Seminars in Cell & Developmental Biology - Volume 60, December 2016, Pages 29-37
نویسندگان
Marius K. Lemberg, Colin Adrain,