Keywords: نابودی دوگانه; Dictyostelium discoideum; Mycobacteria; Dormancy; Lipid droplet; Intracytosolic lipid inclusion; Perilipin; Tb; Tuberculosis; Mtb; Mycobacterium tuberculosis; FAs; fatty acids; TAG; striacylglycerols; LDs; lipid droplets; HCV; hepatitis C virus; ILIs; int
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Keywords: نابودی دوگانه; organic cation transporters (OCTs); renal clearance; hepatic transport; hepatocytes; elderly; AUC; area under the curve; CKD; chronic kidney disease; CVD; cardiovascular disease; FMO3; flavin-containing monooxigenase 3; HEK; human embryonic kidney; HK; h
Keywords: نابودی دوگانه; APP; amyloid precursor protein; APLP; amyloid precursor like protein; APBA1; precursor protein binding, family A; Arc; member 1, activity-regulated cytoskeleton-associated protein; ApoeR2; apolipoprotein E receptor 2; CR; Cajal-Retzius; CASK; calcium/calm
Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration
Keywords: نابودی دوگانه; ER; endoplasmic reticulum; AMD; age-related macular degeneration; RPE; retinal pigment epithelium; PUFAs; polyunsaturated fatty acids; ROS; reactive oxygen species; NRF-2; nuclear factor-erythroid 2-related factor-2; ARE; antioxidant response element; Kea
The epithelial-mesenchymal transition induced by transcription factor LEF-1 is independent of β-catenin
Keywords: نابودی دوگانه; EMT; epithelial-mesenchymal transition; LEF-1; lymphoid-enhancer-binding factor 1; TCF; T-cell factor; KO; knockout; CRISPR; clustered regularly interspaced short palindromic repeats; Cas9; CRISPR-associated 9; PAM; protospacer-adjacent motif; DKO; do
Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse
Keywords: نابودی دوگانه; CESD; cholesteryl ester storage disease; DKO; double knockout; EC; esterified cholesterol; ERT; enzyme replacement therapy; LAL; lysosomal acid lipase; LCAT; lecithin:cholesterol transferase; SOAT1; sterol O-acyltransferase 1; SOAT2; sterol O-acyltransfer
IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal
Keywords: نابودی دوگانه; Arg1; Arginase 1; α-SMA; alpha-smooth muscle actin; ASO; antisense oligonucleotide; BW; body weight; CCL2; chemokine (C-C motif) ligand 2; CCl4; carbon tetrachloride; Col1a1; procollagen α1(I) transcript; DAPI; 4,6-diamidino-2-phenylindole; DKO; doubl
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice
Keywords: نابودی دوگانه; Fatty Liver; Gene Regulation; Hepatic Protection; Mouse Model; Ad; adenovirus; AH; alcoholic hepatitis; ALD; alcoholic liver disease; ALT; alanine aminotransferase; ATP6V0E1; ATPase H+ transporting V0 subunit E1; ATP6V1D; ATPase H+ transporting V1 subunit
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
Keywords: نابودی دوگانه; AAV; adeno-associated virus; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; ADD1; adipocyte determination- and differentiation-dependent factor 1; APP; amyloid precursor protein; Api6; apoptosis inhibitor 6; ApoE; apolipoprotein E; ATF6; activati
Pathophysiological consequences of isoform-specific IP3 receptor mutations
Keywords: نابودی دوگانه; ALS; amyotrophic lateral sclerosis; Bcl-2; B-cell lymphoma-2; CA8; carbonic anhydrase 8 (carbonic anhydrase-related protein); CSCC; cervical squamous cell carcinoma; CTT; C-terminal tail; DKO; double knockout; FAD; familial Alzheimer's disease; GS; Gilles
Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice
Keywords: نابودی دوگانه; AM; adrenomedullin; CGRP; calcitonin gene-related peptide; CLR; calcitonin receptor-like receptor protein; Calcrl; calcitonin receptor-like receptor gene; MAP; mean arterial pressure; RAMP; receptor activity modifying protein; dKO; double knockout; Adreno
Two mammalian homologs of yeast Rad23, HR23A and HR23B, as multifunctional proteins
Keywords: نابودی دوگانه; HR23; homolog of Rad23; GG-NER; global genome nucleotide excision repair; XPC; xeroderma pigmentosum group C; UBL; ubiquitin-like; UBA; ubiquitin-associated; TFIIH; transcription factor IIH; DKO; double knockout; UIM; ubiquitin-interacting motif; HDAC; hi
The IL-1RI Co-Receptor TILRR (FREM1Â Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease
Keywords: نابودی دوگانه; heparan sulfate proteoglycan; interleukin-1 receptor; IL-1RI; NF-κB; TILRR; ApoE; apolipoprotein E; DK; double knockout; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; iBALT; inducible bronchus-associated lymphoid tissue; IgG; immunoglobulin G; IκBα;
MicroRNAs as Important Regulators of Exercise Adaptation
Keywords: نابودی دوگانه; AUC; Area under the curve; CAD; Coronary artery disease; CRF; Cardiorespiratory fitness; CV; Cardiovascular; CVD; Cardiovascular disease; ET; Exercise training; HF; Heart failure; hsa; Homo sapiens (human); HUNT; The Nord-Trøndelag Health Study; HF; Hear
Research ArticleRORγt+ IL-22-producing NKp46+ cells protect from hepatic ischemia reperfusion injury in mice
Keywords: نابودی دوگانه; DKO; double knockout; GPT; glutamate-pyruvate transaminase; IFN; interferon; IL; interleukin; IRI; ischemia reperfusion injury; KO; knockout; NA; necrotic areas; n.d.; not detected; NK22 cells; IL-22-producing NKp46+ cells; PEGF; poor early graft functi
Inactive rhomboid proteins: New mechanisms with implications in health and disease
Keywords: نابودی دوگانه; ADAM17; a disintegrin and metalloproteinase 17; COG; conserved oligomeric Golgi; Der1; degradation in the ER 1; Dfm1; Der1-like family member 1; DKO; double knockout; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; ERAD; ER-associated d
Knockout of GH3 genes in the moss Physcomitrella patens leads to increased IAA levels at elevated temperature and in darkness
Keywords: نابودی دوگانه; Auxin conjugation; GH3 protein; High temperature; Light; Indole-3-acetic acid; Physcomitrella patens; ABA; abscisic acid; ACC; aminocyclopropane carboxylic acid; doKO; double knockout; ET; ethylene; GC-MS; gas chromatography-mass spectrometry; GH3; GR
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
Keywords: نابودی دوگانه; 3-Methyladenine (Pubmed CID 1673); Camptothecin (Pubmed CID 24360); Etoposide (Pubmed CID 36462); 7-Bromoindirubin-3-oxime (Pubmed CID 11846148); Necrostatin-1 (Pubmed CID 282833); Q-VD-OPh (Pubmed CID 11237609); 2-Phenylethynesulfonamide (Pubmed CID 3276
The dense core vesicle protein IA-2, but not IA-2β, is required for active avoidance learning
Keywords: نابودی دوگانه; ANOVA; analysis of variance; CAMKII; Ca2+/calmodulin-dependent protein kinase II; CREB; cAMP response element-binding protein; CS; conditioned stimulus; DCV; dense core vesicles; DKO; double knockout; EDTA; ethylenediaminetetraacetic acid; GBR-12909; a se
NANOS2 promotes male germ cell development independent of meiosis suppression
Keywords: نابودی دوگانه; 5-bromo-2â²-deoxyuridine; BrdU; double knockout; dKO; embryonic day; E; immunoprecipitation; IP; retinoic acid; RA; reverse transcription; RT; phosphate-buffered saline; PBS; polymerase chain reaction; PCR; primordial germ cell; PGC; RNA immunoprecipitat
Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants
Keywords: نابودی دوگانه; BER; base excision repair; BF; bloodstream form; dKO; double knockout; cdKO; conditional double knockout; PAC; puromycin N-acetyl-transferase; HYG; hygromycin phosphotransferase; BSD; blasticidin S deaminase; MTX; methotrexate; Trypanosoma brucei; Deoxyur
Gap junction communication in myelinating glia
Keywords: نابودی دوگانه; A; astrocyte; O; oligodendrocyte; KO; knockout; dKO; double knockout; Gap junction; Hemichannel; Myelinating glia; Intercellular communication; CMTX; PMLD;
Original ResearchFull Report: Basic and Translational-PancreasHippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
Keywords: نابودی دوگانه; Mouse Model; Signal Transduction; Hpo; Wts; AP; acute appendicitis; BrdU; bromodeoxyuridine; CK19; cytokeratin 19; CPA1; carboxypeptidase A1; DKO; double knockout; GFP; green fluorescent protein; TUNEL; terminal deoxynucleotidyl transferase-mediated deo
Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity
Keywords: نابودی دوگانه; APH; aphidicolin; ATG; Autophagy gene; DKO; double knockout; 3-MA; 3-methyl adenine; HU; Hydroxyurea; MEF; mouse embryo fibroblasts; NID; Novel inducer of death; PI3K; phosphotidyl inositol 3-kinase; RIP-1; Receptor Interacting Protein-1, STS, staurospori
Expression of lactoperoxidase in differentiated mouse colon epithelial cells
Keywords: نابودی دوگانه; 129; 129S1/SvlmJ; B6; C57BL/6J; Bmi1; B lymphoma Mo-MLV insertion region 1; COBRA; combined-bisulfite-restriction analysis; DKO; double knockout; DUOX; dual oxidase; EPO; eosinophil peroxidase; GPx; glutathione peroxidase; LPO; lactoperoxidase; MPO; myelo
The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice
Keywords: نابودی دوگانه; Susceptibility; Risk Factor; Mouse Model; Immune Regulation; CD; Crohn's disease; DC; dendritic cells; DKO; double knockout; FACS; fluorescence-activated cell sorter; GWAS; genome-wide association studies; HRP; horseradish peroxidase; IBD; inflammatory bo
Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury
Keywords: نابودی دوگانه; Cholestasis; Canalicular Phospholipid Flippase; Hepatocellular Cancer; PSC; AP; alkaline phosphatase; BA; bile acid; C/EBPα; CCAAT/enhancer binding protein α; CH; cholesterol; DAG; diacylglycerol; DKO; double knockout; FA; fatty acid; FFA; free fatty ac
Colitis and Intestinal Inflammation in IL10â/â Mice Results From IL-13Rα2-Mediated Attenuation of IL-13 Activity
Keywords: نابودی دوگانه; Colitis; Helminth; IBD; Th17; AB-PAS; Alcian blue periodic acid-Schiff; dKO; double knockout; IFN; interferon; IL; interleukin; IL-13Rα2; interleukin-13 decoy receptor; Trichuris muris; T muris;
The role of NPY in hypothalamic mediated food intake
Keywords: نابودی دوگانه; 2-AG; 2-arachidonoylglycerol; AAV; adeno associated virus; AEA; N-arachidonoylethanolamide/anandamide; AgRP; agouti-related peptide; α-MSH; alpha melanocyte stimulating hormone; ARC; arcuate nucleus; BBB; blood-brain barrier; CART; cocaine and amphetam
Genetic reduction of GABAA receptor γ2 subunit expression potentiates the immobilizing action of isoflurane
Keywords: نابودی دوگانه; GABAA receptors; PRIP-1; PRIP-2; Double knockout; Isoflurane; Minimum alveolar concentration;
Meeting ReportThe new therapeutic frontier - Nuclear receptors and the liver
Keywords: نابودی دوگانه; AR (NR3C4); androgen receptor; BA; bile acid; CAR (NR1I3); constitutive androstane receptor; DKO; double knockout; ER (NR3A1); estrogen receptor; FA; fatty acid; FGF; fibroblast growth factor; FXR (NR1H4); farnesoid X receptor/bile acid receptor; GWAS; ge
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009
Keywords: نابودی دوگانه; Dermatology; skin disease; urticaria; atopic dermatitis; anaphylaxis; allergy; hypersensitivity disorders; food; drug; insect venom; ACU; Acquired cold urticaria; AD; Atopic dermatitis; ADEH; Atopic dermatitis with history of eczema herpeticum; ADVN; Atop
Role of Down-Regulated in Adenoma Anion Exchanger in HCO3- Secretion Across Murine Duodenum
Keywords: نابودی دوگانه; Ae4; anion exchanger 4; cAMP; cyclic adenosine monophosphate; BCECF-AM; 2â²,7â²-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein acetoxymethyl ester; Cftr; cystic fibrosis transmembrane conductance regulator; dKO; double knockout; Dra; down-regulated i
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: نابودی دوگانه; 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
BALT development and augmentation of hyperoxic lung injury in mice deficient in NQO1 and NQO2
Keywords: نابودی دوگانه; NQO1, NAD(P)H:quinone oxidoreductase 1; NQO2, NRH:quinone oxidoreductase 2; NRH, dihydronicotinamide riboside; PBS, phosphate-buffered saline; BALT, bronchial-associated lymphoid tissueNQO1; NQO2; Double knockout; BALT; Lung inflammation; Free radicals
Claudin-5 localizes to the lateral membranes of cardiomyocytes and is altered in utrophin/dystrophin-deficient cardiomyopathic mice
Keywords: نابودی دوگانه; Dilated cardiomyopathy; Claudin-5; Duchenne muscular dystrophy; Dystrophin; Intercalated discs; Utrophin; Tight junctions; DCM; dilated cardiac myopathy; Dko; double knockout; DMD; Duchenne muscular dystrophy; JAM; junctional adhesion molecule; mdx; muscu