کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10954448 | 1097905 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Claudin-5 localizes to the lateral membranes of cardiomyocytes and is altered in utrophin/dystrophin-deficient cardiomyopathic mice
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کلمات کلیدی
Intercalated discsMLPDCMDKODMDZO-1mdx - MDXtight junctions - اتصالات محکمUtrophin - اوتوفینTem - این استtot - بهDuchenne muscular dystrophy - دیستروفی عضلانی دوشنDystrophin - دیستروفینJAM - مرباjunctional adhesion molecule - مولکول چسبندگی مجاورTransmission electron microscopy - میکروسکوپ الکترونی عبوریdouble knockout - نابودی دوگانهZonula occludens-1 - نوار ابزار بسته 1Dilated cardiomyopathy - کاردیومیوپاتی دیلاته، کاردیومیوپاتی کاملClaudin-5 - کلودین-5
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Remodeling of adherens junction, gap junction, and desmosomal proteins at the intercalated discs of cardiomyocytes in heart characterizes several animal models of cardiomyopathy, especially dilated cardiac myopathy (DCM). In this study, we show that the tight junction protein, claudin-5, is present in cardiac muscle and localizes to the lateral membranes of cardiomyocytes in normal mice. We further examined claudin-5 in utrophin/dystrophin-deficient (double knockout, dko) mice, a mouse model of muscular dystrophy with cardiomyopathy, and found that claudin-5 mRNA and protein levels are decreased in dko hearts as compared with normal. Intercalated disc cell junction proteins, and another tight junction protein, zonula occludens-1 (ZO-1), are not altered in the dko mouse. Ultrastructural data from dko hearts also shows that the lateral membranes of cardiomyocytes exhibit an abnormal wavy appearance. These data demonstrate that claudin-5 is specifically altered in dko hearts, suggesting that alterations of the lateral membranes of cardiomyocytes, rather than intercalated discs, are associated with cardiomyopathy in the dko mouse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular and Cellular Cardiology - Volume 38, Issue 2, February 2005, Pages 323-332
Journal: Journal of Molecular and Cellular Cardiology - Volume 38, Issue 2, February 2005, Pages 323-332
نویسندگان
Jamie L. Sanford, Jonathan D. Edwards, Tessily A. Mays, Bendi Gong, Anita P. Merriam, Jill A. Rafael-Fortney,