کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6067535 | 1201936 | 2010 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009
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کلمات کلیدی
TLRTSLPdsRNAFLGSEBNHLGDMTCITregASSTEPLOFCDKOOVAAPTACUEACTCSHbdα-galexperimental allergic conjunctivitisIL-10R2ε-Polylysine - e-Polylysinedouble-stranded RNA - RNA دو رشته ایhuman β-defensin - β-defensin انسانAtopy patch test - آزمایش اتوپی پچautologous serum skin test - آزمایش پوست سر اتولوگAllergy - آلِرژیAnaphylaxis - آنافیلاکسی یا بیشدفاعی hypersensitivity disorders - اختلالات حساسیتOvalbumin - اوبلبومینatopic eczema - اگزما اتوپیکCSA - ایالات مؤتلفهٔ آمریکاoral immunotherapy - ایمونوتراپی دهانvenom immunotherapy - ایمونوتراپی زهرskin disease - بیماری پوستیToll-like receptor - تیالآرFood - خوراک یا غذاDrug - داروchronic urticaria - داروی مزمن مزمنDermatology - درماتولوژیAtopic dermatitis - درماتیت آتوپیکGestational diabetes - دیابت بارداریOIT - سازمان بین المللی کارVit - سالDendritic cell - سلول دندریتیکinsect venom - سم حشراتcyclosporin A - سیکلوسپورین AMIF - شهرMacrophage migration inhibitory factor - عامل مهارکننده مهاجرت ماکروفاژPlatelet-activating factor - فاکتور فعال کننده پلاکتfilaggrin - فیلهگرینNon-Hodgkin lymphoma - لنفوم غیر هوچکینThymic stromal lymphopoietin - لنفوپیتین استروما تیمیکRegulatory T - مقررات Ttopical calcineurin inhibitor - مهارکننده کالسیروئین موضعیdouble knockout - نابودی دوگانهknockout - ناکاوتodds ratio - نسبت شانس هاPAF - نیروی هوایی پاکستانvaccinia virus - ویروس واکسیناسیونprostaglandin - پروستاگلاندینهاOral food challenge - چالش خوراک خوراکیUrticaria - کهیرTopical corticosteroid - کورتیکواستروئید موضعیKit - کیتgalactose-α-1,3-galactose - گالاکتوز -α-1،3-گالاکتوز
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This review highlights some of the research advances in anaphylaxis and hypersensitivity reactions to foods, drugs, and insects, as well as advances in allergic skin disease that were reported in the Journal in 2009. Among key epidemiologic observations, several westernized countries report that more than 1% of children have peanut allergy, and there is some evidence that environmental exposure to peanut is a risk factor. The role of regulatory T cells, complement, platelet-activating factor, and effector cells in the development and expression of food allergy were explored in several murine models and human studies. Delayed anaphylaxis to mammalian meats appears to be related to IgE binding to the carbohydrate moiety galactose-α-1,3-galactose, which also has implications for hypersensitivity to murine mAb therapeutics containing this oligosaccharide. Oral immunotherapy studies continue to show promise for the treatment of food allergy, but determining whether the treatment causes tolerance (cure) or temporary desensitization remains to be explored. Increased baseline serum tryptase levels might inform the risk of venom anaphylaxis and might indicate a risk for mast cell disorders in persons who have experienced such episodes. Reduced structural and immune barrier function contribute to local and systemic allergen sensitization in patients with atopic dermatitis, as well as increased propensity of skin infections in these patients. The use of increased doses of nonsedating antihistamines and potential usefulness of omalizumab for chronic urticaria was highlighted. These exciting advances reported in the Journal can improve patient care today and provide insights on how we can improve the diagnosis and treatment of these allergic diseases in the future.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Allergy and Clinical Immunology - Volume 125, Issue 1, January 2010, Pages 85-97
Journal: Journal of Allergy and Clinical Immunology - Volume 125, Issue 1, January 2010, Pages 85-97
نویسندگان
Scott H. MD, Donald Y.M. MD, PhD,