The P2/P2Ⲡsites affect the substrate cleavage of TNF-α converting enzyme (TACE)
Keywords: TNF-α converting enzyme; ADAM17; Peptide-protein docking; Substrate recognition;
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The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages
Keywords: 1,25(OH)2D3 or 1,25D; 1α,25-dihydroxyvitamin D3; ADAM17; ADAM metallopeptidase domain 17; Arf; ADP-ribosylation factor; ASAP2; Arf-GAP with SH3 domain, ankyrin repeat and PH domain 2; B2M; beta-2-microglobulin; ChIA-PET; chromatin interaction analysis wi
A disintegrin and metalloproteinase 17 (ADAM17) mediates epidermal growth factor receptor transactivation by angiotensin II on hepatic stellate cells
Keywords: EGFR transactivation; Angiotensin II; ADAM17; Amphiregulin; Hepatic stellate cell
Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells
Keywords: ADAM17; Post-transcriptional regulation; TNF-α; ERK; Heparan sulfateBAPTA-AM, 1,2-bis(2-aminophenoxy)ethane-N,N,N,N-tetraacetic acid-AM; BPB-PLA2, bromophenacylated PLA2; H2DCFDA, dichlorodihydrofluorescein diacetate; PLA2, Phospholipase A2; ROS, reactive
The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases
Keywords: IL-6 trans-signaling; IL-6R; SNP; ADAM17; Limited proteolysis;
A century old renin-angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
Keywords: RAS; renin-angiotensin system; AOG; angiotensinogen; Ang II; angiotensin II; ACE; angiotensin converting enzyme; ARBs; angiotensin AT1 receptor blockers; Mas R; Mas receptor; TGF-β; transforming growth factor-β; Ang A; angiotensin A; eNOS; endothelial
ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils
Keywords: ADAM; a disintegrin and metalloprotease; Neutrophil; Metalloprotease; ADAM17; Apoptosis; Fc receptor;
Contribution of putative genetic factors and candidate gene variants to inter-individual variation of circulating fractalkine (CX3CL1) levels in a large UK twins' sample
Keywords: ADAM10; ADAM metallopeptidase 10; ADAM17; ADAM metallopeptidase 17; AREG; amphiregulin; DZ; dizygotic twin; LRT; likelihood ratio test; MZ; monozygotic twin; sFRACT; soluble fractalkine; VCA; variance component analysis;
ADAM17 regulates self-renewal and differentiation of U87 glioblastoma stem cells
Keywords: ADAM17; Glioblastoma; Cancer stem cell; Self-renewal; Differentiation;
ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells
Keywords: ADAM17; Epidermal growth factor receptor; Angiotensin II type 1 receptor; Signal transduction; Vascular biology;
Research ReportADAM17 promotes U87 glioblastoma stem cell migration and invasion
Keywords: ADAM17; Glioblastoma; Cancer stem cell; Migration; Invasion;
Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl
Keywords: Hydroquinone; TNF-α; ADAM17; miR-122; p38 MAPK; JNK; AP-1;
The role of intraplatelet reactive oxygen species in the regulation of platelet glycoprotein Ibα ectodomain shedding
Keywords: GP; glycoprotein; ROS; reactive oxygen species; NAC; N-acetylcysteine; DTT; dithiothreitol; MDL; carbobenzoxy-valinyl-phenylalaninal; VWF; von Willebrand factor; GC; glycocalicin; W7; N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide; NEM; N-ethylmaleim
Human breast cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-α cleavage by ADAM17
Keywords: ADAM17; Breast cancer; Cancer-associated fibroblasts; TGF-α; Cell proliferation
Expression analysis of ADAM17 during mouse eye development
Keywords: ADAM17; Gene expression; Embryo; Eye development; Corneal epithelium; Ciliary body epithelial cells; Retinal vessels;
Proteolytic processing of the protein tyrosine phosphatase α extracellular domain is mediated by ADAM17/TACE
Keywords: Receptor protein tyrosine phosphatase; Proteolytic processing; TACE; ADAM17; Ectodomain cleavage
The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II
Keywords: ADAM17; A Disintegrin And Metalloprotease 17; TNF-α; Tumor Necrosis Factor-α; IL-6R; interleukin-6 receptor; IL-1RII; interleukin-1 receptor type II; EGF; Epidermal Growth Factor; MPD; membrane-proximal domain; PMA; phorbol 12-myristate 13-acetate; GPI;
Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics
Keywords: ADAM; a desintegrin and metalloprotease (meltrin-alpha); ADAM12L; a desintegrin and metalloprotease 12 long membrane-bound variant; ADAM12S; a desintegrin and metalloprotease 12 short secreted variant; ADAM17; a desintegrin and metalloprotease17; CDI; inv
A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells
Keywords: Brain tumor; ADAM10; ADAM17;
Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning
Keywords: ADAM, a disintegrin and metalloprotease; APP, amyloid precursor protein; HP, hypoxic preconditioning; SH, severe hypoxiaADAM15; ADAM17; APP; Brain; Hypoxia; Metalloproteases; Neuronal injury and tolerance; Preconditioning
Membrane-Bound and Exosomal Metastasis-Associated C4.4A Promotes Migration by Associating with the α6β4 Integrin and MT1-MMP
Keywords: α6β4; α6β4 integrin; aprotinin; serine protease inhibitor; AS; BSp73AS; AS1B1; AS cells transfected with C4.4A cDNA; ASML; BSp73ASML; FN; fibronectin; HRE; HIF response element; LN; laminin; LN111; formerly LN1; LN332; formerly LN5; MMP14; membrane ty
Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17
Keywords: ADAM17; a disintegrin and metalloproteinase17; mAbs; monoclonal antibodies; ELISA; enzyme-linked immunoabsorbent assay; PMA; phorbol 12-myristate 13-acetate; Human ADAM17; Murine ADAM17; Monoclonal antibodies; ELISA;
ADAM17 regulates TNFα production by placental trophoblasts
Keywords: ADAM17; TNFα; Oxidative stress; Trophoblast; Preeclampsia;
Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain
Keywords: ADAM17; a disintegrin and metalloprotease 17; TNFα; tumor necrosis factor α; IL-6R; interleukin-6 receptor; DN-ADAM17; dominate-negative ADAM17; GPI; glycosylphosphatidylinositol; Mef; mouse embryonic fibroblasts; ADAM17; Metalloprotease; Metzincins; EG
The relationship between ADAM17 promoter polymorphisms and sporadic Alzheimer’s disease in a Northern Chinese Han population
Keywords: ADAM17; Alzheimer’s disease; Promoter; Single nucleotide polymorphism
Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality
Keywords: ADAM17; Kidney disease; Secondary hyperparathyroidism; Renoprotection
Acetylenic inhibitors of ADAM10 and ADAM17: In silico analysis of potency and selectivity
Keywords: ADAM17; TACE; ADAM10; Metalloproteinase inhibition docking; Molecular modeling hydroxamate
The role of calpain in the regulation of ADAM17-dependent GPIbα ectodomain shedding
Keywords: Platelets; Calpain; ADAM17; GPIbα shedding; Chinese hamster ovary cells
Helicobacter pylori CagL Activates ADAM17 to Induce Repression of the Gastric H, K-ATPase α Subunit
Keywords: Helicobacter pylori; CagL; ADAM17; H,K-ATPaseADAM, a disintegrin and metalloprotease; ATPase, adenosine triphosphatase; CagA, cytotoxin-associated gene A; EGFR, epidermal growth factor receptor; ERK, extracellular signal-regulated kinase; HB-EGF, heparin-
Identification of ADAM10 as a major TNF sheddase in ADAM17-deficient fibroblasts
Keywords: Ectodomain shedding; ADAM10; ADAM17; TNF; RNA interference;
In situ evidence of involvement of Schwann cells in ulcerative colitis: autocrine and paracrine signaling by A disintegrin and metalloprotease-17–mediated tumor necrosis factor α production
Keywords: Ulcerative colitis; Schwann cell; ADAM17; TNFα
The role of CXCL16 and its processing metalloproteinases ADAM10 and ADAM17 in the proliferation and migration of human mesangial cells
Keywords: ADAM10; ADAM17; CXCL16; Human mesangial cells; Inflammation; Migration; Proliferation
Sensitization of cerebral tissue in nude mice with photodynamic therapy induces ADAM17/TACE and promotes glioma cell invasion
Keywords: Glioma; Photodynamic therapy; Invasion; ADAM17; EGFR; Akt
Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening
Keywords: Disintegrin; Metalloproteinase; ADAM; TACE; ADAM17; ADAM10; ADAM8; ADAM12; GM6001; TAPI-2; TMI-1; GW9471; Fluorescent; Substrate; Inhibitor; Slow binding; FRET
Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor
Keywords: ADAM17; TNF-α converting enzyme; Metalloproteinase; Propeptide; Processing; Activation
The shedding activity of ADAM17 is sequestered in lipid rafts
Keywords: ADAM17; TACE; TNF-alpha; TNF receptors; Cholesterol; Shedding