کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5534590 | 1551268 | 2017 | 53 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Reactive astrogliosis in stroke: Contributions of astrocytes to recovery of neurological function
ترجمه فارسی عنوان
استرولیوز واگیردار در سکته مغزی: کمکهای آستروسیتها برای بهبود عملکرد عصبی
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کلمات کلیدی
MMPGDNFCSPGATF6αNOSHMGB1TGFβGFAPSTAT3MCATNFαAstrocytes - آستروسیتReactive astrogliosis - آگرولیوز واکنش پذیرGlial scar - اسکار گلیالinterleukin - اینترلوکینTransforming growth factor β - تبدیل فاکتور رشد βtumor necrosis factor-α - تومور نکروز عامل αCNS - دستگاه عصبی مرکزیStroke - سکته مغزیcentral nervous system - سیستم عصبی مرکزیmiddle cerebral artery - شریان مغزی میانیVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)glial-derived neurotrophic factor - فاکتور نوروترفیک مشتق گلیالactivating transcription factor 6α - فعال کردن عامل رونویسی 6αMatrix metalloprotease - ماتریکس متیل پروتئازایsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3nitric oxide synthase - نیتریک اکسید سنتازGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالNeuronal plasticity - پلاستیک نوریchondroitin sulphate proteoglycan - کندرویتین سولفات پروتئگلیکان
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
Alterations in neuronal connectivity, particularly in the “peri-infarct” tissue adjacent to the region of ischemic damage, are important contributors to the spontaneous recovery of function that commonly follows stroke. Peri-infarct astrocytes undergo reactive astrogliosis and play key roles in modulating the adaptive responses in neurons. This reactive astrogliosis shares many features with that induced by other forms of damage to the central nervous system but also differs in details that potentially influence neurological recovery. A subpopulation of astrocytes within a few hundred micrometers of the infarct proliferate and are centrally involved in the development of the glial scar that separates the damaged tissue in the infarct from surrounding normal brain. The intertwined processes of astrocytes adjacent to the infarct provide the core structural component of the mature scar. Interventions that cause early disruption of glial scar formation typically impede restoration of neurological function. Marked reactive astrogliosis also develops in cells more distant from the infarct but these cells largely remain in the spatial territories they occupied prior to stroke. These cells play important roles in controlling the extracellular environment and release proteins and other molecules that are able to promote neuronal plasticity and improve functional recovery. Treatments manipulating aspects of reactive astrogliosis can enhance neuronal plasticity following stroke. Optimising these treatments for use in human stroke would benefit from a more complete characterization of the specific responses of peri-infarct astrocytes to stroke as well as a better understanding of the influence of other factors including age, sex, comorbidities and reperfusion of the ischemic tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurochemistry International - Volume 107, July 2017, Pages 88-103
Journal: Neurochemistry International - Volume 107, July 2017, Pages 88-103
نویسندگان
Neil R. Sims, Wai Ping Yew,