کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5534944 | 1551360 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?
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کلمات کلیدی
FGFR2CYP19A1cytochrome P450 family 11 subfamily A member 1FGF9HmgSF1WT1Cyp26b1WNT4Rspo1Wilms tumor 1Sox8DPCNTDR-spondin 1sex determining region YBMP2cytochrome P450 family 19 subfamily A member 1Forkhead box L2foxl2CTDPGD2TESSox9Sex determination - تعیین جنسیتGonadal development - توسعه گونادالC-terminal domain - دامنه C ترمینالN-terminal domain - دامنه N-terminalRetinoic acid - رتینوئیک اسیدdays post coitum - روز پس از مقاربتSertoli cell - سلول سرتولیSry - سوریFibroblast growth factor 9 - عامل رشد فیبروبلاست 9bone morphogenetic protein 2 - پروتئین مورفوژنیک استخوان 2Prostaglandin D2 - پروستاگلاندین D2Prostaglandin D2 synthase - پروستاگلاندین D2 سنتازhigh mobility group - گروه تحرک بالاfibroblast growth factor receptor 2 - گیرنده فاکتور رشد فیبروبلاست 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In mammals, sex determination defines the differentiation of the bipotential genital ridge into either testes or ovaries. Sry, the mammalian Y-chromosomal testis-determining gene, is a master regulator of male sex determination. It acts to switch the undifferentiated genital ridge towards testis development, triggering the adoption of a male fate. Sry initiates a cascade of gene networks through the direct regulation of Sox9 expression and promotes supporting cell differentiation, Leydig cell specification, vasculature formation and testis cord development. In the absence of Sry, alternative genetic cascades, including female sex-determining genes RSPO1, Wnt4/β-catenin and Foxl2, are involved in the formation of female genitalia and the maintenance of female ovarian development. The mutual antagonisms between male and female sex-determining pathways are crucial in not just the initiation but also the maintenance of the somatic sex of the gonad throughout the organism's lifetime. Any imbalances in above sex-determining genes can cause disorders of sex development in humans and mice. In this review, we provide a detailed summary of the expression profiles, biochemical properties and developmental functions of Sry and SoxE genes in embryonic testis development and adult gonadal development. We also briefly summarize the dedicate balances between male and female sex-determining genes in mammalian sex development, with particular highlights on the molecular actions of Sry and Sox9 transcription factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Cell & Developmental Biology - Volume 63, March 2017, Pages 13-22
Journal: Seminars in Cell & Developmental Biology - Volume 63, March 2017, Pages 13-22
نویسندگان
Zhen-Yu She, Wan-Xi Yang,