کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5536220 | 1551704 | 2017 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Recurrent tuberculosis in an urban area in China: Relapse or exogenous reinfection?
ترجمه فارسی عنوان
سل ریوی مجدد در یک منطقه شهری در چین: عود مجدد یا عفونت مجدد خارجی
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کلمات کلیدی
بیماری سل، عود، عفونت مجدد خارجی چین،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Recurrent tuberculosis is an important indicator of the effectiveness of tuberculosis control and can occur by relapse or exogenous reinfection. We conducted a retrospective cohort study on all bacteriologically confirmed tuberculosis cases that were successfully treated between 2000 and 2012 in Shanghai, an urban area with a high number but a low prevalence rate of tuberculosis cases and a low prevalence of HIV infection. Genotyping the Mycobacterium tuberculosis from clinical isolates was used to distinguish between relapse and reinfection. In total, 5.3% (710/13,417) of successfully treated cases had a recurrence, a rate of 7.55 (95% CI 7.01-8.13) episodes per 1000 person-years, more than 18 times the rate of tuberculosis in the general population. Patients who were male, age 30-59, retreatment cases, had cavitation, diabetes, drug-resistant or multidrug-resistant tuberculosis in their initial episode of tuberculosis, were at high risk for a recurrence. Among 141 recurrent cases that had paired isolates, 59 (41.8%) had different genotypes, indicating reinfection with a different strain. Patients who completed treatment were still at high risk of another episode of tuberculosis and exogenous reinfection contributed a significant proportion of the recurrent tuberculosis cases. Targeted control strategies are needed to prevent new tuberculosis infections in this setting.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 103, March 2017, Pages 97-104
Journal: Tuberculosis - Volume 103, March 2017, Pages 97-104
نویسندگان
Xin Shen, Chongguang Yang, Jie Wu, Senlin Lin, Xu Gao, Zheyuan Wu, Jiyun Tian, Mingyu Gan, Tao Luo, Lili Wang, Chenlei Yu, Jian Mei, Qichao Pan, Kathryn DeRiemer, ZhengAn Yuan, Qian Gao,