کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5542715 | 1402522 | 2016 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats
ترجمه فارسی عنوان
پنیر بز از التهاب روده بر روی کولیت ناشی از اسید استیک در موش صحرایی می کند
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کلمات کلیدی
پنیر بز التهاب روده، استرس اکسیداتیو، سیتوکین ها، ایمونوهیستوشیمی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
چکیده انگلیسی
Complementary or alternative medicine is of great interest for the treatment of inflammatory bowel disease, with the aim of ameliorating the side effects of the drugs commonly used or improving their efficacy. In this study, we evaluated the ability of goat whey to prevent intestinal inflammation in the experimental model of acetic acid-induced rats and compared it to sulfasalazine. Pretreatment with goat whey (1, 2, and 4 g/kg) and sulfasalazine (250 mg/kg) on colitic rats improved colonic inflammatory markers, including myeloperoxidase activity, leukotriene B4 levels, as well as the production of proinflammatory cytokines IL-1β and tumor necrosis factor-α. Furthermore, the administration of goat whey significantly reduced the colonic oxidative stress by reducing malondialdehyde levels and increased total glutathione content, a potent antioxidant peptide. The histological evaluation of the colonic specimens from colitic rats confirmed these beneficial effects, as goat whey preserved the colonic tissue, especially in those rats treated with the highest dose of goat whey or with sulfasalazine. The immunohistochemistry analysis of the colonic tissue evaluation also revealed a reduction in the expression of cyclooxygenase-2, inducible nitric oxide synthase, and matrix metalloproteinase-9, together with an increased expression of suppressor of cytokine signaling-1. These results suggest that goat whey exerted a preventive effect against the intestinal damage induced by acetic acid, showing a similar efficacy to that shown by sulfasalazine, therefore making it a potential treatment for human inflammatory bowel disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dairy Science - Volume 99, Issue 12, December 2016, Pages 9383-9394
Journal: Journal of Dairy Science - Volume 99, Issue 12, December 2016, Pages 9383-9394
نویسندگان
Daline Fernandes de Souza Araújo, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araújo Júnior, Aurigena Antunes de Araújo, Paloma Oliveira Antonino de Assis, Ariosvaldo Nunes de Medeiros, Yasmim Regis Formiga de Sousa,