کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5543896 1554297 2017 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of melamine with or without cyanuric acid on immune function in ovalbumin-sensitized mice
ترجمه فارسی عنوان
اثرات ملامین با یا بدون اسید سیانوریک بر عملکرد ایمنی در موش های حساسیت شده به تخم آلبومین
کلمات کلیدی
ملایم، اسید سیانوریک، عملکرد ایمنی، اوالوبومین، ماوس،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
چکیده انگلیسی
Melamine is commonly used in the chemical industry, and it has been found to exist on food processing equipment and utensils. Previous investigations suggested that melamine alone or its combination with cyanuric acid appears to be toxic to immune system in animals. The objective of this study is to investigate the potential effects of melamine with or without cyanuric acid on immune function in ovalbumin- sensitized mice. Our data indicated that melamine-related administration caused a significant decreasing in the content of IL-4 in mice in comparison to negative control group. Significant increasing in the content of histamine (HIS) was recorded in almost all treated groups. The co-administration of melamine and cyanuric acid with high dose (each at 16 mg kg− 1 2 d− 1) led to a significantly lower contents of IL-10, IL-16 and monocyte chemoattractant protein-1 (MCP-1) in mouse serum in comparison to negative control group. Moreover, our data indicated that the number of Th1 and Th2 cells, and the ratio of Th1/Th2 spleen lymphocytes were significantly changed after treatment. Also, our results demonstrated that the profiles of both CD40 and CD40L were significantly altered in spleen lymphocytes after treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 114, October 2017, Pages 254-261
نویسندگان
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