کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5543902 | 1554297 | 2017 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel effects of identified SNPs within the porcine Pregnancy-Associated Glycoprotein gene family (pPAGs) on the major reproductive traits in Hirschmann hybrid-line sows
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
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چکیده انگلیسی
All identified SNPs were verified for possible pPAG2-L genotype associations with the major reproductive traits. In total, 196 SNPs were identified within the entire structure of the pPAG2-Ls, encompassing 9 exons and 8 (A-H) introns, resembling all aspartic proteinases. It was discovered that among all SNPs, one diplotype localized in exon 6 (657C > T/749G > C; pPAG2 ORF cDNA numbering; L34361) caused amino acid substitutions (Asp220 â Asn and Ser250 â Thr) in the polypeptide precursors and was associated with an increase in the number of live-born piglets (P â¤Â 0.05) in Hrn sows. In turn, co-localized SNP (504g > a; KF537535 numbering) in the intron F of the pPAG2-Ls, but only in the homozygotic genotype (gg), was associated with an increased number of live-born (P â¤Â 0.01) and weaned (P â¤Â 0.05) piglets in the Hrn sows. These results qualify the pPAG2-Ls as candidate genes of the main QTLs. The novel pPAG SNP profiles provide the basis for a diagnostic genotyping test required for early pre-selection of female/male piglets, presumably mainly useful in various breeding herds.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Research in Veterinary Science - Volume 114, October 2017, Pages 123-130
Journal: Research in Veterinary Science - Volume 114, October 2017, Pages 123-130
نویسندگان
Grzegorz Panasiewicz, Martyna Bieniek-Kobuszewska, Aleksandra Lipka, Marta Majewska, Roman Jedryczko, Bozena Szafranska,