کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5546237 1555904 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human transmission of Ebola virus
ترجمه فارسی عنوان
انتقال انسان از ویروس ابولا
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ویروس شناسی
چکیده انگلیسی


- Principal transmission mode of EBOV is through close contact with contaminated fluids.
- Currently no evidence to suggest aerosol transmission in a natural setting.
- West African 2014 EBOV Makona strain not evolving faster than previous strains.
- Evidence of positive selection in several viral genes including GP.
- Changes linked to viral replication complex and surface glycoprotein expression.

Ever since the first recognised outbreak of Ebolavirus in 1976, retrospective epidemiological analyses and extensive studies with animal models have given us insight into the nature of the pathology and transmission mechanisms of this virus. In this review focusing on Ebolavirus, we present an outline of our current understanding of filovirus human-to-human transmission and of our knowledge concerning the molecular basis of viral transmission and potential for adaptation, with particular focus on what we have learnt from the 2014 outbreak in West Africa. We identify knowledge gaps relating to transmission and pathogenicity mechanisms, molecular adaptation and filovirus ecology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Virology - Volume 22, February 2017, Pages 51-58
نویسندگان
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