Optimization of paeonol-loaded poly(butyl-2-cyanoacrylate) nanocapsules by central composite design with response surface methodology together with the antibacterial properties

Here, we report the preparation of Paeonol-loaded poly(butyl-2-cyanoacrylate) nanocapsules (Pae@PNCs) by interfacial spontaneous polymerization. The response surface methodology (RSM) in a rotatable central composite design (RCCD) has also been successfully applied to optimize the experimental conditions for drug delivery systems, which optimize preparation Pae@PNCs with highest EE% (73.58 ± 2.76%), the smallest particle size (42.06 ± 1.20 nm) and homogeneous distribution. Finally, the release profiles and antibacterial activity in vitro from optimal Pae@PNCs were also performed.93