کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5548042 | 1556463 | 2017 | 11 صفحه PDF | دانلود رایگان |
The recent strategy uses a distinct approach to modify diffusional barrier of the hair and utilising the pharmaceutical benefits of microemulsion to facilitate follicular permeability of Minoxidil. Various attempts were made to optimise pre-treatment and post treatment conditions, which cause the hair follicles to swell up and shrink using conventional reagents. Microemulsions prepared with oleic acid, PEG 600 and span 20 using pseudo ternary diagrams. Optimised microemulsion for topical delivery (globule size- 41.0Â nm; zeta potential-Â +28.22Â mV; transmittance- 98.1%) was considered for drug delivery. In-vitro release of 68.5% after 24Â hrs was observed and ex-vivo studies showed 67.5% drug retention inside hair shaft. Prepared formulation significantly altered the follicular response in 5-Fluorouracil induced alopecia model. It opens a new avenue for delivery of drugs via transfollicular route in the treatment of follicular diseases.
Innovative drug delivery strategies for hair fall treatment.203
Journal: Journal of Drug Delivery Science and Technology - Volume 41, October 2017, Pages 113-123