کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5548074 | 1556463 | 2017 | 8 صفحه PDF | دانلود رایگان |
Folate is widely used as a target ligand for tumor cells, and poly (l-aspartic acid)-b-poly-(l-phenylalanine) (PAA-PPA) is a biodegradable material with low immunogenicity and toxicity. In this study, to enhance the targeting effect, folate-conjugated PAA-PPA micelles were synthesized. To evaluate the hypothesis, we assessed the pharmacokinetics and biodistribution of a new antitumor drug 4-amino-2-trifluoromethyl-phenyl retinate (ATPR) loaded into the micelles. We also observed in vivo imaging of 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindotricarbocyanine iodide (DiR) loaded micelles to confirm distribution. The results showed that ATPR-loaded, folate-modified PAA-PPA displayed a prolonged circulation half-life and improved the targeting effect.
178
Journal: Journal of Drug Delivery Science and Technology - Volume 41, October 2017, Pages 436-443