Nanocarrier mediated combination drug delivery for chemotherapy - A review

Nanoscale delivery system has more applications in cancer treatment owing to their controlled and targeted drug release with reduced systemic cell toxicity and reduced drug adverse effects. Combination of multiple chemotherapy drugs helps to control cancer cell at different clinical stages of synergistic action, varying mechanism of action and suppressing drug resistance. Delivering drug combination chemotherapeutics in Nanocarrier base proves promising in advanced therapeutic approach on cancer cells by the enhanced pharmacokinetics of different drugs, reduced drug drug interaction and tailored drug release pattern. This article provides a brief review of various concepts behind coloading of multiple chemotherapeutic drugs in different types of nanoscale carriers and multidrug loaded nanocarriers for anticancer treatment.

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