کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5548245 | 1556468 | 2016 | 7 صفحه PDF | دانلود رایگان |
Nanoemulsions (NE) are advantageous nanosized delivery agents for ophthalmic medications because of their ability to penetrate into the ocular structure, as well as their sustained effects. We prepared a NE system composed of isopropyl myristate, triacetin, Tween 80, and ethyl alcohol to increase the solubility and permeability of lutein, an effective medication in macular degeneration. The pseudo-ternary phase diagram was constructed to identify the self-emulsifying region. Eight formulations were selected to characterize each formulation. We examined physical characteristics including particle size, drug solubility, formulation stability, and turbidity. We selected the optimized formulations NE 5 (NE-5) and NE-8, both of which are transparent. The particle size of NE was ca. 10-12Â nm with a narrow size distribution. Neither separation nor change in the particle size was observed for 7 days. The lutein loading NEs demonstrated a significant increase in lutein release and sustained release. In contrast, lutein prepared with oil and starch had limited drug release profiles under 5%. The prepared lutein NE formulation is a potential alternative for lutein delivery systems.
Journal: Journal of Drug Delivery Science and Technology - Volume 36, December 2016, Pages 168-174