کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548790 1556594 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of analgesics on central processing of tonic pain: A cross-over placebo controlled study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The effects of analgesics on central processing of tonic pain: A cross-over placebo controlled study
چکیده انگلیسی


- Oxycodone decreased delta and theta spectral indices of EEG to tonic pain.
- Oxycodone decreased the brain activity underlying delta and theta EEG bands.
- Venlafaxine decreased alpha spectral indices of EEG to tonic pain.
- Brain activity underlying lower EEG frequencies is likely important in opioid analgesia.
- Alpha EEG activity is likely important in SNRI analgesia.

IntroductionOpioids and antidepressants that inhibit serotonin and norepinephrine reuptake (SNRI) are recognized as analgesics to treat moderate to severe pain, but the central mechanisms underlying their analgesia remain unclear. This study investigated how brain activity at rest and exposed to tonic pain is modified by oxycodone (opioid) and venlafaxine (SNRI).MethodsTwenty healthy males were included in this randomized, cross-over, double-blinded study. 61-channel electroencephalogram (EEG) was recorded before and after five days of treatment with placebo, oxycodone (10 mg extended release b.i.d) or venlafaxine (37.5 mg extended release b.i.d) at rest and during tonic pain (hand immersed in 2 °C water for 80 s). Subjective pain and unpleasantness scores of tonic pain were recorded. Spectral analysis and sLORETA source localization were done in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta1 (12-18 Hz) and beta2 (18-32 Hz) frequency bands.ResultsOxycodone decreased pain and unpleasantness scores (P < 0.05), whereas venlafaxine decreased the pain scores (P < 0.05). None of the treatments changed the spectral indices or brain sources underlying resting EEG. Venlafaxine decreased spectral indices in alpha band of the EEG to tonic pain, whereas oxycodone decreased the spectral indices and brain source activity in delta and theta frequency bands (all P < 0.05). The brain source activity predominantly decreased in the insula and inferior frontal gyrus.ConclusionThe decrease of activity within insula and inferior frontal gyrus is likely involved in pain inhibition due to oxycodone treatment, whereas the decrease in alpha activity is likely involved in pain inhibition due to venlafaxine treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 123, 1 September 2017, Pages 455-464
نویسندگان
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