کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5548900 1556596 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo
چکیده انگلیسی


- Medial prefrontal cortex HFS induces corticostriatal LTD in vivo.
- Prefrontostriatal HFS-LTD is dopamine and CB1 receptor independent in vivo.
- In vivo, prefrontostriatal HFS-LTD does not require striatal cholinergic interneurons.
- Pharmacological NMDA receptor blockade blocks prefrontostriatal HFS-LTD in vivo.

Repetitive stimulation of cognitive forebrain circuits at frequencies capable of inducing corticostriatal long term plasticity is increasingly being used with therapeutic purposes in patients with neuropsychiatric disorders. However, corticostriatal plasticity is rarely studied in the intact brain. Our aim was to study the mechanisms of corticostriatal long term depression (LTD) induced by high frequency stimulation (HFS) of the medial prefrontal cortex in vivo. Our main finding is that the LTD induced in the dorsomedial striatum by medial prefrontal cortex HFS in vivo (prefrontostriatal LTD) is not affected by manipulations that block or reduce the LTD induced in the dorsolateral striatum by motor cortex HFS in brain slices, including pharmacological dopamine receptor and CB1 receptor blockade, chronic nigrostriatal dopamine depletion, CB1 receptor genetic deletion and selective striatal cholinergic interneuron (SCIN) ablation. Conversely, like in the hippocampus and other brain areas, prefrontostriatal LTD is NMDA receptor dependent. Thus, we describe a novel form of corticostriatal LTD that operates in brain circuits involved in reward and cognition and could be relevant for understanding the therapeutic effects of deep brain stimulation.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuropharmacology - Volume 121, 15 July 2017, Pages 278-286
نویسندگان
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