کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555078 1559630 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Two new steroidal glycosides with unique structural feature of 14α-hydroxy-5β-steroids from Reineckia carnea
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Two new steroidal glycosides with unique structural feature of 14α-hydroxy-5β-steroids from Reineckia carnea
چکیده انگلیسی

Two new steroidal glycosides (1-2) were isolated from the roots of Reineckia carnea, together with three known compounds (3-5). Their structures were determined on the basis of chemical methods and spectral data. Compounds 1-2 were the unique steroidal glycosides possessing structural feature of 14α-hydroxy-5β-steroids, and compounds 4-5 were isolated from R. carnea for the first time. The isolated compounds (1-5) were tested in vitro for their cytotoxic activities against the A549, HepG 2 and Caski cancer cell lines. Among them, the compounds 2 and 3 showed cytotoxicity against Caski cancer cell line with IC50 values of 34.4 and 3.7 μM, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 115, December 2016, Pages 19-23
نویسندگان
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