کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5555131 1559627 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity
چکیده انگلیسی

Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7 ± 0.5 and 14.1 ± 3.5 μM, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 118, April 2017, Pages 126-131
نویسندگان
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