کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5559626 1561688 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cellular pathways involved in silica nanoparticles induced apoptosis: A systematic review of in vitro studies
ترجمه فارسی عنوان
مسیرهای سلولی مربوط به نانوذرات سیلیکا باعث آپوپتوز می شوند: بررسی سیستماتیک مطالعات آزمایشگاهی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی

Silica nanoparticles (SiNPs) have been found to pass through biological barriers and get distributed in the human body. They induce cell apoptosis via various mechanisms in body organs. To understand these mechanisms, we carried out systematic review of in vitro studies on SiNPs-induced cell apoptosis. Office of Health Assessment and Translation approach for Systematic Review and Evidence Integration was used to identify 14 studies dating from the year 2000 to current. Four studies showed an increase in DNA damage, cell cycle arrest, proapoptotic factors and decrease in antiapoptotic factors resulting to apoptosis. Eight studies showed induction of mitochondrial dysfunction, Bax upregulation, Bcl-2 downregulation, and caspase-3, −7, −9 activities increase. Increase in FADD, TNFR1 and Bid proteins was observed in one study, while the other NO production and caspase-3 activity was increased. These studies found the potency of SiNPs to induce cell apoptosis through DNA damage, mitochondrial, tumor necrosis factor, and nitric oxide related pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 56, December 2017, Pages 191-197
نویسندگان
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