Interest of metabonomic approach in environmental nephrotoxicants: Application to aristolochic acid exposure

- Mode of action of aristolochic acids nephrotoxicity was assessed by metabonomics in rats.
- A metabonomic signature characteristic of proximal tubule injury was observed.
- Dose-dependent effects were detected by metabonomics at early stages and morphologically confirmed at later time points.
- Renal damages were more pronounced with the mixture or AAII alone than AAI alone.