کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560056 1403308 2017 30 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Liver toxicity related to herbs and dietary supplements: Online table of case reports. Part 2 of 5 series
ترجمه فارسی عنوان
سمیت کبدی مربوط به گیاهان و مکمل های غذایی: جدول آنلاین گزارش موارد. قسمت 2 از سری 5
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی

BackgroundNo online current list of potentially life-threatening, hepatotoxic herbs and dietary supplements based on PubMed case reports exists in a summarized tabular form.MethodsDocumented case reports of herbs or dietary supplements (DS; includes herbs) appearing to contribute to liver injury were used to create an online “DS Toxic Table” of potentially hepatotoxic herbs and dietary supplements (PubMed, 1966 to June, 2016, and cross-referencing). The spectrum of DS induced liver injuries (DSILI) included elevated liver enzymes, hepatitis, steatosis, cholestasis, hepatic necrosis, hepatic fibrosis, hepatic cirrhosis, veno-occlusive disease, acute liver failure requiring a liver transplant, and death.ResultsOver the past 50 years, approximately 21 herbs (minus germander and usnic acid that are no longer sold) and 12 dietary supplements (minus the nine no longer sold and vitamin A & niacin due to excess intake) posed a possible risk for liver injures in certain individuals. The herbs with the most number of reported publications (but not cases studies) in descending order, were germander, black cohosh, kava extract, and green tea extract.ConclusionThese online DS Toxic Tables will contribute to continued Phase IV post marketing surveillance to detect possible liver toxicity cases and serve to forewarn consumers, clinicians, and corporations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 107, Part A, September 2017, Pages 472-501
نویسندگان
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