کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560228 1561742 2017 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Safety assessment of mushrooms in dietary supplements by combining analytical data with in silico toxicology evaluation
ترجمه فارسی عنوان
ارزیابی ایمنی قارچ ها در مکمل های غذایی با ترکیب داده های تحلیلی در ارزیابی سمیکولوژی سیلیکا
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی
Despite growing popularity in dietary supplements, many medicinal mushrooms have not been evaluated for their safe human consumption using modern techniques. The multifaceted approach described here relies on five key principles to evaluate the safety of non-culinary fungi for human use: (1) identification by sequencing the nuclear ribosomal internal transcribed spacer (ITS) region (commonly referred to as ITS barcoding), (2) screening an extract of each fungal raw material against a database of known fungal metabolites, (3) comparison of these extracts to those prepared from grocery store-bought culinary mushrooms using UHPLCPDA-ELS-HRMS, (4) review of the toxicological and chemical literature for each fungus, and (5) evaluation of data establishing presence in-market. This weight-of-evidence approach was used to evaluate seven fungal raw materials and determine safe human use for each. Such an approach may provide an effective alternative to conventional toxicological animal studies (or more efficiently identifies when studies are necessary) for the safety assessment of fungal dietary ingredients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 103, May 2017, Pages 133-147
نویسندگان
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