کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560417 1403319 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trans fatty acids and cholesterol levels: An evidence map of the available science
ترجمه فارسی عنوان
اسیدهای چرب ترانس و سطوح کلسترول: یک نقشه مدرن از علم موجود
کلمات کلیدی
کلسترول، بیماری قلب و عروقی، مارگارین، چربی های ترانس،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- Since FDA's 2003 TFA labeling regulation, intakes of iTFA have decrease from >6% to ∼0.5% en.
- Limited data are available on low level iTFA intakes from PHOs and LDL-C.
- Limited evidence is available to determine the effect of iTFA at current consumption on CHD risk.

High intakes of industrial trans fatty acids (iTFA) increase circulating low density lipoprotein cholesterol (LDL-C) levels, which has implicated iTFA in coronary heart disease (CHD) risk. Published data on iTFA and LDL-C, however, represent higher intake levels than the U.S. population currently consume. This study used state-of-the-art evidence mapping approaches to characterize the full body of literature on LDL-C and iTFA at low intake levels. A total of 32 independent clinical trials that included at least one intervention or control group with iTFA at ≤3%en were found. Findings indicated that a wide range of oils and interventions were used, limiting the ability to determine an isolated effect of iTFA intake. Few data points were found for iTFA at <3%en, with the majority of low-level exposures actually representing control group interventions containing non-partially hydrogenated (PHO) oils. Further, it appears that few dose-response data points are available to assess the relationship of low levels of iTFA, particularly from PHO exposure, and LDL-C. Therefore, limited evidence is available to determine the effect of iTFA at current consumption levels on CHD risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 98, Part B, December 2016, Pages 269-281
نویسندگان
, , , , ,