کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560851 | 1562034 | 2017 | 6 صفحه PDF | دانلود رایگان |
- A2â²S/G mutations in RDL GABA receptor confer cyclodiene resistance in various pests.
- A2â²S/G mutations confer low level of cross resistance to fipronil.
- A2â²N mutation in RDL GABA receptor confers fipronil resistance in planthoppers.
- PCR-RFLP assays were developed for detecting fipronil-resistant planthoppers.
- There is a need to develop novel insecticides effective against A2â² mutations.
Lindane and cyclodienes, such as dieldrin and α-endosulfan, represent the first generation of noncompetitive antagonists (NCAs) against the insect RDL GABA receptor. It has been reported that A2â²S and A2â²G mutations in the membrane-spanning region M2 of the RDL GABA receptor confer resistance to lindane and cyclodienes. Fipronil is a second-generation NCA, but A2â²S and A2â²G mutations provide a low level of cross-resistance to fipronil. Moreover, a novel A2â²N mutation that confers fipronil resistance was found in M2 of the RDL GABA receptors from fipronil-resistant planthoppers in the heterozygous state. Thus, problems are being caused by a worldwide appearance of cyclodiene-resistant pests. And attention must be paid to development of fipronil-resistant planthoppers, such as Sogatella furcifera and Laodelphax striatellus in Japan.
Journal: NeuroToxicology - Volume 60, May 2017, Pages 293-298