کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560870 1562036 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Parkinson's disease-like motor and non-motor symptoms in rotenone-treated zebrafish
ترجمه فارسی عنوان
علائم بیماری پارکینسون مانند موتور و غیر حرکتی در سگ های دریایی تحت درمان با روتنون
کلمات کلیدی
بیماری پارکینسون، علائم غیر حرکتی روتنون، ماهی قزل آلا،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- The motor ability of zebrafish may be impaired after rotenone exposure for 4 weeks.
- The zebrafish showed anxiety-like behavior following rotenone exposure.
- Olfactory dysfunction was observed in rotenone-exposed zebrafish.
- The decreased DA level may account for the PD-like symptoms in rotenone group.

The pesticide rotenone is widely used to produce Parkinson's disease (PD)-like symptoms in rodents, but few studies have examined whether rotenone-treated zebrafish can serve as an animal model of PD. Here, we report that 4 weeks of rotenone treatment induced motor and non-motor PD-like symptoms in adult zebrafish. Compared with control fish, rotenone-treated fish spent less time swimming at a fast speed, indicating a deficit in motor function. In the light-dark box test, rotenone-treated fish exhibited longer latencies to enter the dark compartment and spent more time in the light compartment, reflecting anxiety- and depression-like behavior. Furthermore, rotenone-treated fish showed less of an olfactory preference for amino acid, indicating olfactory dysfunction. These behavioral symptoms were associated with decreased levels of dopamine in the brains of rotenone-treated fish. Taken together, these results suggest that rotenone-treated zebrafish are a suitable model of PD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroToxicology - Volume 58, January 2017, Pages 103-109
نویسندگان
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