Characterization of an acquired jumping translocation involving 3q13.31-qter in a patient with de novo acute monocytic leukemia

Duplication of 3q13.31-qter might be a non-random chromosomal abnormality with concomitant submicroscopic deletion at 3q13.31 occurring in rare cases of acute monocytic leukemia, being associated with adverse prognosis. The impact of shortened telomeres in forming the JT is reviewed.