کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5588065 1404515 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Continuous glucose monitoring adds information beyond HbA1c in well-controlled diabetes patients with early cardiovascular autonomic neuropathy
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Continuous glucose monitoring adds information beyond HbA1c in well-controlled diabetes patients with early cardiovascular autonomic neuropathy
چکیده انگلیسی


- The presence of CAN is associated with loss of postpradial glucose control in noninsulin-treated Patients with type 2 diabetes.
- The association was observed despite comparable HbA1c levels in patients with vs. without CAN.
- These findings emphasize the importance of monitoring glucose patterns over 24-h and not only rely on HbA1c in patients with CAN.

AimsHyperglycemia as evaluated by HbA1c is a risk factor for the development of cardiovascular autonomic neuropathy (CAN). The aim of the present study was to investigate whether continuous glucose monitoring (CGM) may add information beyond HbA1c in patients with type 2 diabetes and CAN.Methods81 patients with type 2 diabetes (43 men, mean age 58 ± 11 year, HbA1c 6.6 ± 0.5%). Patients were tested for CAN using cardiovascular reflex tests (response to standing, deep breathing and Valsalva maneuver) and underwent CGM for three days. CAN was defined as early (one test abnormal), or manifest (two or three tests abnormal).ResultsTwenty patients had early CAN and two patients had manifest CAN. Blood pressure, HbA1c, cholesterol levels and smoking habits were comparable in patients with vs. without CAN. Post-breakfast glycemic peak was significantly higher in patients with CAN (peak 207 vs 176 mg/dL, P = 0.009). Furthermore, the nocturnal glucose drop and dawn glucose was significantly higher in patients with CAN compared with patients without CAN (mean 134 vs. 118 mg/dL, P = 0.017 and mean 143 vs. 130 mg/dL, P = 0.045, respectively). Removing the two patients with manifest CAN from the statistical analysis didn't change the results.ConclusionsThese findings emphasize the importance of monitoring glucose patterns over 24-h and not only rely on HbA1c as therapeutic target in patients with type 2 diabetes and CAN.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Diabetes and its Complications - Volume 31, Issue 9, September 2017, Pages 1389-1393
نویسندگان
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