کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5589914 | 1569840 | 2017 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulatory roles of microRNAs in human dental tissues
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کلمات کلیدی
OdontogenesisSpecial AT-rich sequence-binding protein 2SCAPSDFCsDPCsSATB2DSPPECMPDLCCDnon-coding RNAs - RNA های غیر کدگذاریGene expression - بیان ژنTooth development - توسعه دندانPeriodontal ligament - رباط پریودنتالstem cells from apical papilla - سلول های بنیادی از پاپیل آپیکالیdental follicle cells - سلول های فولیکول دندانیdental pulp cells - سلول های پالپ دندانdentin sialophosphoprotein - سیلوفوسفوپروتئین دنتینVascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Extracellular matrix - ماتریکس خارج سلولیMicroRNA - میکرو RNA MiRNA - میکروRNA، ریزآرانای، miRNA
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
MicroRNAs (miRNAs) are a class of small, non-coding RNAs that provide an efficient pathway for regulation of gene expression at a post-transcriptional level. Tooth development is regulated by a complex network of cell-cell signaling during all steps of organogenesis. Most of the congenital dental defects in humans are caused by mutations in genes involved in developmental regulatory networks. Whereas the developmental morphological stages of the tooth development already are thoroughly documented, the implicated genetic network is still under investigation. The involvement of miRNAs in the regulation of tooth genetic network was suggested for the first time in 2008. MiRNAs regulate tooth morphogenesis by fine-tuning the signaling networks. Unique groups of miRNAs are expressed in dental epithelium compared with mesenchyme, as well as in molars compared with incisors. The present review focuses on the current state of knowledge on the expression and function of miRNAs in human dental tissues, including teeth and the surrounding structures. Herein, we show that miRNAs exhibit specific roles in human dental tissues and are involved in gingival and periodontal disease, tooth movement and eruption, dental pulp physiology including repair and regeneration, differentiation of dental cells, and enamel mineralization. In light of similarities between the tooth development and other organs originating from the epithelium, further understanding of miRNAs` function in dental tissues may have wide biological relevance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 596, 5 January 2017, Pages 9-18
Journal: Gene - Volume 596, 5 January 2017, Pages 9-18
نویسندگان
Amer Sehic, Amela Tulek, Cuong Khuu, Minou Nirvani, Lars Peter Sand, Tor Paaske Utheim,