کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5590720 1570157 2016 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differences among HIV-1 subtypes in drug resistance against integrase inhibitors
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک بوم شناسی، تکامل، رفتار و سامانه شناسی
پیش نمایش صفحه اول مقاله
Differences among HIV-1 subtypes in drug resistance against integrase inhibitors
چکیده انگلیسی
Three integrase strand transfer inhibitors (INSTIs), raltegravir (RAL), elvitegravir (EVG) and dolutegravir (DTG), have been approved by the FDA. Resistance against these three INSTIs have been reported and cross-resistance among them has been documented. Due to extensive and dynamic genetic diversity in different HIV-1 variants, significant differences in susceptibility to the INSTIs have been observed among HIV subtypes. This review summarizes what is known about this topic and discusses possible clinical implications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infection, Genetics and Evolution - Volume 46, December 2016, Pages 286-291
نویسندگان
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