Accuracy and Radiation Dose Reduction Using Low-Voltage Computed Tomography Coronary Artery Calcium Scoring With Tin Filtration

This study prospectively investigated the accuracy and radiation dose reduction of CT coronary artery calcium scoring (CACS) using a 100 kVp acquisition protocol with tin filtration (Sn100 kVp) compared with the standard 120 kVp acquisition protocol; 70 patients (59% men, 62.1 ± 10.7 years) who underwent a clinically indicated CACS acquisition using the standard 120 kVp protocol on a third-generation dual-source CT system were enrolled. An additional Sn100 kVp CACS scan was performed. Agatston scores and categories, percentile-based risk categorization, and radiation dose estimates were derived from 120 and Sn100 kVp studies and compared. Median Agatston scores from the Sn100 and 120 kVp acquisitions were 38.2 and 41.2, respectively (p <0.0001). Excellent correlation of Agatston scores was found between the 2 acquisitions (r = 0.99, p <0.0001). Although the Agatston scores were systematically lower with Sn100 than with 120 kVp, the comparison of Agatston score categories and percentile-based cardiac risk categories showed excellent agreement (κ = 0.98 and κ = 0.98). Image noise was 26.3 ± 5.7 Hounsfield units in Sn100 kVp and 17.6 ± 4.1 Hounsfield units in 120 kVP scans (p <0.0001). The dose-length product was 14.1 ± 3.7 mGy·cm with Sn100 kVp and 58.5 ± 23.5 mGy·cm with 120 kVp scans (p <0.0001), resulting in a significantly lower effective radiation dose (0.19 ± 0.05 vs 0.82 ± 0.32 mSv, p <0.0001) for Sn100 kVp scans. CACS using a low-voltage tin filtration protocol shows excellent correlation and agreement with the standard method with regard to the Agatston score and subsequent cardiac risk categorization, while achieving a 75% reduction in radiation dose.