کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5595750 1573117 2017 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathophysiologic Mechanisms in Heart Failure: Role of the Sympathetic Nervous System
ترجمه فارسی عنوان
مکانیسم های پاتوفیزیولوژیک در نارسایی قلب: نقش سیستم عصبی سمپاتیک
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
The syndrome of heart failure involves complex pathophysiologic mechanisms and is associated with extremely high-morbidity, mortality and economic costs. This growing global epidemic has diverse etiologies and is fundamentally characterized by dyshomeostasis between heart and kidneys, leading to development and progression of the cardiorenal syndrome. Excessive and sustained sympathoexcitation has emerged as a single prominent factor involved in the structural and functional dysfunction of multiple organ systems during this disease. Studies in experimental models of heart failure indicate that ablation of the renal nerves may help restore renal sodium and water equilibrium as well as the attenuation of adverse cardiac remodeling. With the recent development of minimally invasive endovascular renal denervation in humans, it is anticipated that this technology would become a novel and important paradigm shift in the management of heart failure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The American Journal of the Medical Sciences - Volume 353, Issue 1, January 2017, Pages 27-30
نویسندگان
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