کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5600464 | 1405297 | 2017 | 22 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Epithelial-Derived Cytokines in Asthma
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کلمات کلیدی
AHRASMTSLPhmAbThymic stromal lymphopoietin receptorTSLPRAsthma - آسمhuman monoclonal antibody - آنتی بادی منوکلونال انسانیTight junction - اتصال تنگAirway inflammation - التهاب راه های هواییDendritic cell - سلول دندریتیکCytokines - سیتوکین هاAirway smooth muscle - عضله صاف راه هواییThymic stromal lymphopoietin - لنفوپیتین استروما تیمیکairway hyper-responsiveness - پاسخ سریع هواپیما
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
The interaction between the airway epithelium and the inhaled environment is crucial to understanding the pathobiology of asthma. Several studies have identified an important role of airway epithelial-derived cytokines, IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) in asthma pathogenesis. These cytokines have been described as epithelial-derived alarmins that activate and potentiate the innate and humoral arms of the immune system in the presence of actual or perceived damage. Each of the three epithelial-derived alarmins has been implicated in the pathobiology of inhaled allergen-induced airway responses. The best evidence to date exists for TSLP, in that a human monoclonal antibody, which binds TSLP and prevents its engagement with its receptor, resolves airway inflammation in patients with allergic asthma and attenuates allergen-induced airway responses. Better understanding the roles that the epithelial-derived alarmins play and how they influence airway immune response may allow the development of novel therapeutics for asthma treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chest - Volume 151, Issue 6, June 2017, Pages 1338-1344
Journal: Chest - Volume 151, Issue 6, June 2017, Pages 1338-1344
نویسندگان
Patrick D. MD, Paul M. MD, FCCP,