کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5602344 | 1575719 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genetic Effects on the Correlation Structure of CVD Risk Factors
ترجمه فارسی عنوان
اثرات ژنتیکی بر ساختار همبستگی عوامل خطر بیماری قلبی عروقی
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Plasma concentration of plasminogen activator inhibitor-1 (PAI-1) is highly correlated with several cardiovascular disease (CVD) risk factors. It also plays a direct role in CVD, including myocardial infarction and stroke, by impeding the dissolution of thrombi in the blood. Insofar as PAI-1 links CVD's risk factors to its endpoints, genetic variants modulating the relationship between PAI-1 and risk factors may be of particular clinical and biological interest. The high heritability of PAI-1, which has not been explained by genetic association studies, may also, in large part, be due to this relationship with CVD risk factors. Using exome-wide data from 1,032 Ghanaian study participants, we tested for heterogeneity of correlation by genotype between PAI-1 and 4 CVD risk factors (body mass index, triglycerides, mean arterial pressure, and fasting glucose) under the hypothesis that loci involved in the relationship between PAI-1 and other risk factors will also modify their correlational structure. We found more significant heterogeneities of correlation by genotype than we found marginal effects, with no evidence of type I inflation. The most significant result among all univariate and multivariate tests performed in this study was the heterogeneity of correlation between PAI-1 and mean arterial pressure at rs10738554, near SLC24A2, a gene previously associated with high blood pressure in African Americans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Global Heart - Volume 12, Issue 2, June 2017, Pages 133-140
Journal: Global Heart - Volume 12, Issue 2, June 2017, Pages 133-140
نویسندگان
Nuri Kodaman, Rafal S. Sobota, Folkert W. Asselbergs, Matthew T. Oetjens, Jason H. Moore, Nancy J. Brown, Melinda C. Aldrich, Scott M. Williams,