کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5604171 1576100 2017 31 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased inflammation promotes ventricular arrhythmia through aggravating left stellate ganglion remodeling in a canine ischemia model
ترجمه فارسی عنوان
افزایش التهاب باعث ارتقای آریتمی بطنی از طریق تشدید مجدد گانگلیون ستاره چپ در مدل ایسکمی سگ
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Schematic diagram illustrating how IL-1β injection into LSG aggravates ischemia induced VA. Normally, cardiac ischemia activates afferent signals to the LSG and results in mild inflammation and increased expression of excitatory neurotransmitters (NGF and NPY), as well as increased inhibitory neurotransmitters (nNOS). The inconsistent up-regulation between excitatory and inhibitory neurotransmitters contributes to the increased LSG activity and subsequent incidence of VA. However, IL-1β injection into the LSG results in more prominent inflammatory response. The increased inflammation in the LSG promotes the expression of excitatory neurotransmitters, but suppresses the inhibitory neurotransmitters, which aggravates the imbalance between excitatory and inhibitory neurotransmitters in the LSG and results in significantly increased LSG activity and more incidence of VA. While, IL-1Ra pre-injection could attenuate the pro-arrhythmic effects of IL-1β through regulating the neural remodeling processes.203
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Cardiology - Volume 248, 1 December 2017, Pages 286-293
نویسندگان
, , , , , , , , , , , , ,