کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5613691 | 1578012 | 2017 | 30 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of gender and adiposity on in vivo vascular function in young African Americans
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of gender and adiposity on in vivo vascular function in young African Americans Effect of gender and adiposity on in vivo vascular function in young African Americans](/preview/png/5613691.png)
چکیده انگلیسی
The relationship between obesity and high blood pressure is not as strong among African Americans (AA) as compared to Caucasians. We designed the current study to determine the effect of adiposity on vascular endothelial function (a harbinger of hypertension) among young healthy AA without additional cardiovascular disease risk factors. A total of 108 AA subjects (46 women) between the ages of 18 and 45 years were recruited. All the subjects were normotensive, nonsmokers, and normoglycemic. Anthropometric and cardiovascular disease risk factor measurements (lipid, insulin resistance, and inflammatory markers) were obtained. Vascular endothelial function was measured by brachial artery flow-mediated dilation (FMD). Adiposity distribution was measured by using magnetic resonance imaging scan. There were no gender differences in age and levels of blood pressure, lipids, insulin resistance, and inflammatory markers. Women had higher total body fat percentage and higher peripheral adiposity compared to men. We observed that total and central adiposity did not correlate significantly with brachial artery FMD in women (r = â0.12 and r = 0.23, respectively; P = NS). However, in men, waist circumference was positively associated with FMD (r = 0.3, P ⤠.05). Hyperemic flow was negatively correlated significantly with total and central adiposity in men (r = â0.34 and r = â0.48, respectively; P < .05), but not in women (r = â0.26 and r = 0.03, respectively; P = NS). Our study suggests that increased adiposity may pose greater risk to AA men compared to AA women by adversely affecting resistance vessel function (as measured by hyperemic flow). Larger studies are necessary to validate these findings.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American Society of Hypertension - Volume 11, Issue 5, May 2017, Pages 246-257
Journal: Journal of the American Society of Hypertension - Volume 11, Issue 5, May 2017, Pages 246-257
نویسندگان
Namrata MD, Sindhu BS, Brittaney BS, RN, Andrea MPH, RD, Shanthi MBBS, MPH, Michael E. MD, MPH, Srividya MD, MS,