کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5618837 1406042 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ArticleFermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های درون ریز و اتونومیک
پیش نمایش صفحه اول مقاله
Original ArticleFermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety
چکیده انگلیسی


- Fermentable carbohydrate protects against diet-induced obesity via FFAR2.
- Fermentable carbohydrate increases GLP-1 cell density independently of FFAR2.
- FFAR2 signaling increases PYY cell density and circulating PYY concentration.

ObjectiveDietary supplementation with fermentable carbohydrate protects against body weight gain. Fermentation by the resident gut microbiota produces short-chain fatty acids, which act at free fatty acid receptor 2 (FFAR2). Our aim was to test the hypothesis that FFAR2 is important in regulating the beneficial effects of fermentable carbohydrate on body weight and to understand the role of gut hormones PYY and GLP-1.MethodsWild-type or Ffar2−/− mice were fed an inulin supplemented or control diet. Mice were metabolically characterized and gut hormone concentrations, enteroendocrine cell density measurements were carried out. Intestinal organoids and colonic cultures were utilized to substantiate the in vivo findings.ResultsWe provide new mechanistic insight into how fermentable carbohydrate regulates metabolism. Using mice that lack FFAR2, we demonstrate that the fermentable carbohydrate inulin acts via this receptor to drive an 87% increase in the density of cells that produce the appetite-suppressing hormone peptide YY (PYY), reduce food intake, and prevent diet-induced obesity.ConclusionOur results demonstrate that FFAR2 is predominantly involved in regulating the effects of fermentable carbohydrate on metabolism and does so, in part, by enhancing PYY cell density and release. This highlights the potential for targeting enteroendocrine cell differentiation to treat obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Metabolism - Volume 6, Issue 1, January 2017, Pages 48-60
نویسندگان
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