Letter to the Editors-in-ChiefFactor VII Tokushima (Cys22 → Gly) is not γ-carboxylated due to a disrupted γ-carboxylase recognition site

- Sequencing and functional analysis show no γ-carboxylation of factor VII Tokushima.
- Lack of γ-carboxylation explains < 1% procoagulant activity of factor VII Tokushima.
- The factor VII Tokushima mutation (C22G) disrupts a γ-carboxylase recognition site.
- The γ-carboxylase recognition site is common to proteins homologous to factor VII.