کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626130 1579513 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewEffect of endoscopic pyloric therapies for patients with nausea and vomiting and functional obstructive gastroparesis
ترجمه فارسی عنوان
بررسی تأثیر درمانهای پیلوریک آندوسکوپی برای بیماران مبتلا به تهوع و استفراغ و گاستاپراسیس انسدادی عملکردی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


- We identified a subset of patients with functional obstructive gastroparesis.
- These patients had normal 3 cpm gastric myoelectrical activity and normal endoscopy.
- 33 patients had at least one pyloric Botox injection or pyloric balloon dilation.
- Overall, 78% of the 33 patients reported improvement in gastroparesis symptoms.
- Average weight gain was 1.54 lb from baseline to final treatment (p < 0.04).

Gastroparesis (GP) is associated with loss of interstitial cells of Cajal (ICCs) and gastric dysrhythmias such as tachygastria. We hypothesized that a subset of patients with GP, normal 3 cycles per minute (cpm) gastric myoelectrical activity (GMA), and normal upper endoscopy may respond to pyloric therapies.AimsTo determine the effect of botulinum toxin A (btA) injection or balloon dilation (BD) of the pylorus on symptoms and body weight in patients with GP and 3 cpm GMA.MethodsPatients were identified who had GP, normal 3 cpm GMA, and normal endoscopy that excluded mechanical obstruction of the pylorus. Electrogastrograms (EGG) with water load tests (WLT) were recorded to determine GMA. Gastric emptying was measured with 4 h scintigraphy. Each patient underwent up to three pyloric treatments with btA or BD.ResultsThirty-three patients (29 women) with an average age of 42 years were studied. Seventy-nine percent had idiopathic GP and 21% had diabetic GP. The average percent meal retained at 4 h was 42% and each EGG test showed normal 3 cpm GMA. Nausea was the major symptom in 76% of patients. Complete or partial symptom response occurred in 75%, 72%, and 88% of patients after the first, second, or third endoscopic pyloric treatment, respectively. Overall, 78% of the 33 patients reported improvement in symptoms and average weight gain was 1.54 lb from baseline to final treatment (p < 0.04).ConclusionPyloric therapies appear to be effective treatments in symptomatic patients with GP and 3 cpm GMA and controlled trials are warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Autonomic Neuroscience - Volume 202, January 2017, Pages 56-61
نویسندگان
, , , , ,