کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626332 1406316 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleDiffusion restriction in the corticospinal tracts and the corpus callosum in neonates after cerebral insult
ترجمه فارسی عنوان
مقاله اصلی محدودیت دیفیوژن در کورتیکاسپسنال و کولوسوسوم کبد در نوزادان پس از سکته مغزی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

BackgroundIn neonatal brains diffusion restriction, which is not limited to the region of insult, but is also found in distant locations from it seems to be a frequent finding, called pre-Wallerian degeneration.ObjectivesThe purpose of this study was to describe these findings and to estimate the frequency of their occurrence with an attempt to determine their clinical significance.Methods125 brain MRI examinations of neonates with confirmed brain damage performed or consulted in our Institute were retrospectively reviewed, focusing on the presence of restricted diffusion in corticospinal tracts (CST) and corpus callosum (CC). Apparent diffusion coefficients (ADC) were measured in callosal splenium and compared to normal neonatal brains.ResultsRestricted diffusion was found in 21 newborns (16.8%): in 4 in CST (3.2%), in 5 in CC (4.0%), in 12 in both (9.6%). Mean ADC value in CC was 0.638, standard deviation (SD): 0.211 μm2/s and in the control group 0.995, SD: 0.162 μm2/s (p = 0,001).ConclusionsNeonatal brain MRI should be searched for DWI abnormalities which are not rare and require careful studying of ADC maps. Diffusion restriction in the corpus callosum and/or corticospinal tracts below the region of insult should not be mistaken for acute ischemia as it most likely reflects early phase of secondary neuronal degeneration called pre-Wallerian degeneration. This finding helps in prognostication and guides the management of the affected neonates.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 39, Issue 3, March 2017, Pages 203-210
نویسندگان
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